Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1839319 | 0.81 | HPGD (0.51) | HPGDMAPTCYP19A1CYP3A4 | |
| SCHEMBL9699641 | 0.81 | HPGD (0.51) | HPGDMAPTTSHRCYP19A1HSD17B10 | |
| SCHEMBL7314011 | 0.78 | MAPT (0.57) | HPGDMAPTTSHRALDH1A1KMT2A | |
| SCHEMBL7314541 | 0.76 | SIRT6 (0.57) | HPGDMAPTTSHRCYP19A1CYP3A4 | |
| SCHEMBL7325260 | 0.76 | HPGD (0.46) | HPGDMAPTTSHRHSD17B10CYP3A4 | |
| SCHEMBL4908896 | 0.76 | MAPT (0.46) | HPGDMAPTTSHRALDH1A1KDM4E | |
| SCHEMBL29697321 | 0.75 | HPGD (0.51) | HPGDMAPTTSHRCYP19A1HSD17B10 | |
| SCHEMBL10727148 | 0.75 | HPGD (0.51) | HPGDMAPTTSHRCYP19A1HSD17B10 | |
| SCHEMBL4764865 | 0.75 | HPGD (0.51) | HPGDMAPTTSHRALDH1A1POLB | |
| SCHEMBL12841361 | 0.74 | CYP1A2 (0.47) | HPGDMAPTCYP3A4ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4900839-A | SUBSTITUTED PHENYLPROPENAMIDES | PFIZER INC. (US) | 1990-02-13 | — | — | US | disclosed |
| US-4837334-A | Precursors to quinolone inotropic agents | PFIZER INC. (US) | 1989-06-06 | — | — | US | disclosed |
| US-4783467-A | Tetrahydroimidazoquinazolinone inotropic agents | PFIZER INC. (US) | 1988-11-08 | — | — | US | disclosed |
| US-4728653-A | CONGESTIVE HEART FAILURE | PFIZER INC. (US) | 1988-03-01 | — | — | US | disclosed |
| CN-85104392-A | The preparation method of quinolone inotropic agents | — | 1986-12-24 | — | — | CN | disclosed |
| EP-0205280-A2 | Tetrahydroimidazoquinazolinone cardiac stimulants | Pfizer Limited (GB) | 1986-12-17 | — | — | EP | disclosed |
| EP-0166533-A1 | Quinolone inotropic agents | Pfizer Limited (GB) | 1986-01-02 | — | — | EP | disclosed |