Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | AR | P10275 | 10/20 | 0.52 |
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | PGR | P06401 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7311809 | 0.76 | HPGD (0.56) | POLBCYP3A4CYP1A2CYP2C9TSHR | |
| SCHEMBL961124 | 0.76 | SIRT6 (0.77) | SIRT6ARLMNASMN1; SMN2CYP3A4 | |
| SCHEMBL6498189 | 0.76 | LMNA (0.62) | SIRT6POLBARLMNASMN1; SMN2 | |
| SCHEMBL1353320 | 0.75 | SIRT6 (0.59) | SIRT6POLBARLMNASMN1; SMN2 | |
| SCHEMBL960384 | 0.75 | LMNA (0.61) | SIRT6POLBARLMNASMN1; SMN2 | |
| SCHEMBL12478451 | 0.75 | SIRT6 (0.75) | SIRT6LMNASMN1; SMN2CYP3A4CYP1A2 | |
| SCHEMBL28137192 | 0.75 | SIRT6 (0.75) | SIRT6LMNASMN1; SMN2CYP3A4CYP1A2 | |
| SCHEMBL29351198 | 0.74 | SIRT6 (0.54) | SIRT6POLBARLMNASMN1; SMN2 | |
| SCHEMBL213627 | 0.74 | SIRT6 (0.54) | SIRT6POLBARLMNASMN1; SMN2 | |
| SCHEMBL5174342 | 0.74 | SIRT6 (0.54) | SIRT6POLBARLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4900839-A | SUBSTITUTED PHENYLPROPENAMIDES | PFIZER INC. (US) | 1990-02-13 | — | — | US | disclosed |
| US-4837334-A | Precursors to quinolone inotropic agents | PFIZER INC. (US) | 1989-06-06 | — | — | US | disclosed |
| US-4728653-A | CONGESTIVE HEART FAILURE | PFIZER INC. (US) | 1988-03-01 | — | — | US | disclosed |
| EP-0166533-A1 | Quinolone inotropic agents | Pfizer Limited (GB) | 1986-01-02 | — | — | EP | disclosed |