Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | AR | P10275 | 2/20 | 0.41 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9699641 | 0.82 | HPGD (0.51) | HPGDMAPTPOLBTSHRCYP1A2 | |
| SCHEMBL11901195 | 0.78 | PTGS1 (0.47) | MAPTPOLBALDH1A1PTGS2MEN1 | |
| SCHEMBL1836548 | 0.78 | HPGD (0.47) | HPGDARSIRT6MAPTPOLB | |
| SCHEMBL4908896 | 0.77 | MAPT (0.46) | HPGDMAPTTSHRALDH1A1KDM4E | |
| SCHEMBL7311809 | 0.76 | HPGD (0.56) | HPGDMAPTPOLBTSHRALDH1A1 | |
| SCHEMBL12402474 | 0.75 | HPGD (0.47) | HPGDMAPTPOLBTSHRPTGS2 | |
| SCHEMBL11901675 | 0.75 | TLR2 (0.38) | TSHRALDH1A1PTGS2CYP3A4PTGS1 | |
| SCHEMBL11901049 | 0.74 | TLR2 (0.48) | TSHRALDH1A1PTGS2SMN1; SMN2MEN1 | |
| SCHEMBL1831803 | 0.74 | TRPC3 (0.50) | HPGDTSHRKDM4EPTGS2LMNA | |
| SCHEMBL8819363 | 0.73 | PTGS2 (0.40) | TSHRPTGS2LMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4900839-A | SUBSTITUTED PHENYLPROPENAMIDES | PFIZER INC. (US) | 1990-02-13 | — | — | US | disclosed |
| US-4837334-A | Precursors to quinolone inotropic agents | PFIZER INC. (US) | 1989-06-06 | — | — | US | disclosed |
| US-4728653-A | CONGESTIVE HEART FAILURE | PFIZER INC. (US) | 1988-03-01 | — | — | US | disclosed |
| CN-85104392-A | The preparation method of quinolone inotropic agents | — | 1986-12-24 | — | — | CN | disclosed |
| EP-0166533-A1 | Quinolone inotropic agents | Pfizer Limited (GB) | 1986-01-02 | — | — | EP | disclosed |