Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 11/20 | 1.00 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.39 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7311429 | 0.91 | ECE1 (0.83) | ECE1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4196934 | 0.88 | ECE1 (1.00) | ECE1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7308033 | 0.78 | ECE1 (1.00) | ECE1MAPTGFER | |
| SCHEMBL7322148 | 0.78 | ECE1 (0.77) | ECE1 | |
| SCHEMBL7317687 | 0.75 | ECE1 (1.00) | ECE1MAPT | |
| SCHEMBL3549517 | 0.73 | PLA2G4A (0.60) | ECE1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL27867999 | 0.73 | PLA2G4A (0.60) | ECE1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3698353 | 0.72 | PLA2G4A (0.57) | ECE1MAPTPLA2G4A | |
| SCHEMBL7323063 | 0.71 | ECE1 (1.00) | ECE1 | |
| SCHEMBL7321910 | 0.68 | ECE1 (0.60) | ECE1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5891892-A | Small molecule biaryl compounds as inhibitors of endothelin converting enzyme | WARNER-LAMBERT COMPANY (US) | 1999-04-06 | — | — | US | claimed |
| US-5891892-A | Small molecule biaryl compounds as inhibitors of endothelin converting enzyme | WARNER-LAMBERT COMPANY (US) | 1999-04-06 | — | — | US | disclosed |