Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 10/20 | 1.00 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | KDM4B | O94953 | 1/20 | 0.39 |
| ▸ | KDM5C | P41229 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | NEK2 | P51955 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7322763 | 0.88 | ECE1 (0.79) | ECE1KDM4EPDE10A | |
| SCHEMBL7322148 | 0.79 | ECE1 (0.77) | ECE1GPR35ALOX15KDM4EALDH1A1 | |
| SCHEMBL7308033 | 0.79 | ECE1 (1.00) | ECE1GPR35ALOX15KDM4EKDM4A | |
| SCHEMBL7317687 | 0.76 | ECE1 (1.00) | ECE1ALOX15KDM4EALDH1A1 | |
| SCHEMBL7312652 | 0.71 | ECE1 (1.00) | ECE1 | |
| SCHEMBL4196934 | 0.68 | ECE1 (1.00) | ECE1GPR35 | |
| SCHEMBL1683807 | 0.68 | ECE1 (0.51) | ECE1 | |
| SCHEMBL7317692 | 0.68 | ECE1 (0.54) | ECE1GPR35ALOX15KDM4EALDH1A1 | |
| SCHEMBL7318992 | 0.68 | ECE1 (0.79) | ECE1ALOX15KDM4EALDH1A1 | |
| SCHEMBL7321910 | 0.68 | ECE1 (0.60) | ECE1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5891892-A | Small molecule biaryl compounds as inhibitors of endothelin converting enzyme | WARNER-LAMBERT COMPANY (US) | 1999-04-06 | — | — | US | claimed |
| US-5891892-A | Small molecule biaryl compounds as inhibitors of endothelin converting enzyme | WARNER-LAMBERT COMPANY (US) | 1999-04-06 | — | — | US | disclosed |