Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 7/20 | 0.83 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7312652 | 0.91 | ECE1 (1.00) | ECE1HDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL4196934 | 0.79 | ECE1 (1.00) | ECE1HDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL7318992 | 0.79 | ECE1 (0.79) | ECE1MAPTGFERHPGDTSHR | |
| SCHEMBL7321910 | 0.79 | ECE1 (0.60) | ECE1MAPTHPGDTSHRKDM4E | |
| SCHEMBL7321772 | 0.77 | ECE1 (0.82) | ECE1MAPTHPGDTSHRKDM4E | |
| SCHEMBL7322763 | 0.72 | ECE1 (0.79) | ECE1HDAC8HPGDTSHRKDM4E | |
| SCHEMBL7308033 | 0.68 | ECE1 (1.00) | ECE1MAPTGFERKDM4E | |
| SCHEMBL7322148 | 0.68 | ECE1 (0.77) | ECE1KDM4E | |
| SCHEMBL7317687 | 0.68 | ECE1 (1.00) | ECE1MAPTHPGDTSHRKDM4E | |
| SCHEMBL5691492 | 0.67 | ADORA3 (0.41) | ECE1HDAC1HDAC6HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5891892-A | Small molecule biaryl compounds as inhibitors of endothelin converting enzyme | WARNER-LAMBERT COMPANY (US) | 1999-04-06 | — | — | US | disclosed |