Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 11/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.41 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7321910 | 0.88 | ECE1 (0.60) | ECE1HSD17B10ALDH1A1KDM4EMEN1 | |
| SCHEMBL7308033 | 0.87 | ECE1 (1.00) | ECE1KDM4ERAB9AGPR35ALOX15 | |
| SCHEMBL7317687 | 0.84 | ECE1 (1.00) | ECE1HSD17B10ALDH1A1KDM4EMEN1 | |
| SCHEMBL7323063 | 0.79 | ECE1 (1.00) | ECE1ALDH1A1KDM4EGPR35ALOX15 | |
| SCHEMBL7312652 | 0.78 | ECE1 (1.00) | ECE1 | |
| SCHEMBL7318992 | 0.75 | ECE1 (0.79) | ECE1HSD17B10ALDH1A1KDM4EMEN1 | |
| SCHEMBL7363044 | 0.75 | ALDH1A1 (0.59) | HSD17B10ALDH1A1KDM4EMEN1NPC1 | |
| SCHEMBL4196934 | 0.75 | ECE1 (1.00) | ECE1MEN1GPR35 | |
| SCHEMBL7321772 | 0.73 | ECE1 (0.82) | ECE1HSD17B10ALDH1A1KDM4EMEN1 | |
| SCHEMBL1308428 | 0.69 | TUBB4A (0.61) | ALDH1A1KDM4EMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5891892-A | Small molecule biaryl compounds as inhibitors of endothelin converting enzyme | WARNER-LAMBERT COMPANY (US) | 1999-04-06 | — | — | US | claimed |
| US-5891892-A | Small molecule biaryl compounds as inhibitors of endothelin converting enzyme | WARNER-LAMBERT COMPANY (US) | 1999-04-06 | — | — | US | disclosed |