Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | ACHE | P22303 | 5/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9761125 | 0.98 | TSHR (0.51) | SMN1; SMN2ALDH1A1ACHETSHRKDM4E | |
| SCHEMBL13212401 | 0.90 | SMN1; SMN2 (0.57) | SMN1; SMN2ALDH1A1ACHETSHRKDM4E | |
| SCHEMBL10964426 | 0.88 | MEN1 (0.43) | SMN1; SMN2LTA4HL3MBTL1 | |
| SCHEMBL10967093 | 0.87 | ACHE (0.48) | SMN1; SMN2ALDH1A1ACHETSHRLTA4H | |
| SCHEMBL10597046 | 0.81 | RAB9A (0.49) | SMN1; SMN2ALDH1A1TSHRKDM4ELTA4H | |
| SCHEMBL4803036 | 0.81 | ABCB1 (0.47) | SMN1; SMN2LTA4HLMNAL3MBTL1 | |
| SCHEMBL4474585 | 0.80 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1ACHETSHRKDM4E | |
| SCHEMBL17941049 | 0.79 | KDM4E (0.55) | SMN1; SMN2ALDH1A1ACHETSHRKDM4E | |
| SCHEMBL1303146 | 0.78 | LTA4H (0.62) | SMN1; SMN2ALDH1A1LTA4HLMNAPOLB | |
| SCHEMBL53331 | 0.78 | PPID (0.49) | SMN1; SMN2ALDH1A1TSHRLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4647565-A | 2-(2-quinazolinylaminoalkoxymethyl)-1,4-dihydropyridine derivatives as cardiovascular agents | PFIZER INC. (US) | 1987-03-03 | — | — | US | disclosed |
| US-4572909-A | 2-(Secondary aminoalkoxymethyl) dihydropyridine derivatives as anti-ischaemic and antihypertensive agents | PFIZER INC. (US) | 1986-02-25 | — | — | US | disclosed |
| EP-0168151-A1 | Dihydropyridine cardiovascular agents | Pfizer Limited (GB) | 1986-01-15 | — | — | EP | disclosed |
| EP-0060674-B1 | DIHYDROPYRIDINE ANTI-ISCHAEMIC AND ANTIHYPERTENSIVE AGENTS, PROCESSES FOR THEIR PRODUCTION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Pfizer Limited (GB) | 1985-09-18 | — | — | EP | disclosed |
| US-4430333-A | Dihydropyridine anti-ischaemic and antihypertensive agents | PFIZER INC. (US) | 1984-02-07 | — | — | US | disclosed |
| EP-0089167-A2 | Dihydropyridine anti-ischaemic and antihypertensive agents, processes for their production, and pharmaceutical compositions containing them | Pfizer Limited (GB) | 1983-09-21 | — | — | EP | disclosed |
| EP-0060674-A1 | Dihydropyridine anti-ischaemic and antihypertensive agents, processes for their production, and pharmaceutical compositions containing them | Pfizer Limited (GB) | 1982-09-22 | — | — | EP | disclosed |