SCHEMBL7313518

SCHEMBL7313518

CCOC(=O)CC(C(=O)OCC)N1CCN(CC2CN(C3CCN(C(=N)NC(=O)OC(C)(C)C)CC3)C(=O)O2)CC1

nearest known ligand 0.38

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HTR2B P41595 4/20 0.38
ITGB3 P05106 1/20 0.34
ITGA2B P08514 1/20 0.34
MEN1 O00255 1/20 0.31
ALDH1A1 P00352 1/20 0.31
TSHR P16473 1/20 0.31
KMT2A Q03164 1/20 0.31
LMNA P02545 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7318688 0.88 HTR2B (0.43) HTR2BITGB3ITGA2B
SCHEMBL7315730 0.88 ITGB3 (0.33) HTR2BITGB3ITGA2BLMNA
SCHEMBL7307552 0.87 ITGB3 (0.34) HTR2BITGB3ITGA2B
SCHEMBL7303222 0.86 ITGB3 (0.32) ITGB3ITGA2BLMNA
SCHEMBL7304230 0.86 HTR2B (0.43) HTR2BITGB3ITGA2BLMNA
SCHEMBL7308042 0.85 ITGB3 (0.34) HTR2BITGB3ITGA2B
SCHEMBL7308612 0.85 ITGB3 (0.34) HTR2BITGB3ITGA2B
SCHEMBL7303264 0.82 HTR2B (0.38) HTR2BITGB3ITGA2B
SCHEMBL7306776 0.82 HTR2B (0.46) HTR2BITGB3ITGA2BLMNA
SCHEMBL7303588 0.82 GAA (0.32) HTR2BITGB3ITGA2BMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0727425-A1 Adhesion receptor antagonists MERCK PATENT GmbH (DE) 1996-08-21 EP disclosed