Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | DRD4 | P21917 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | EP300 | Q09472 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4045639 | 0.85 | KDM1A (0.34) | DRD2DRD4OPRM1DRD3KDM1A | |
| SCHEMBL733341 | 0.84 | KDM1A (0.35) | DRD2DRD4OPRM1DRD3KDM1A | |
| SCHEMBL731436 | 0.82 | KDM1A (0.35) | DRD2DRD4OPRM1DRD3KDM1A | |
| SCHEMBL731083 | 0.81 | DRD2 (0.33) | DRD2DRD4OPRM1DRD3KDM1A | |
| SCHEMBL733031 | 0.80 | KDM1A (0.36) | KDM1ASYKEP300CREBBPPGR | |
| SCHEMBL733371 | 0.79 | KDM1A (0.31) | KDM1A | |
| SCHEMBL731222 | 0.78 | PGR (0.43) | DRD2DRD4OPRM1DRD3KDM1A | |
| SCHEMBL4445905 | 0.77 | KDM1A (0.34) | DRD2DRD4OPRM1DRD3KDM1A | |
| SCHEMBL733454 | 0.76 | KDM1A (0.39) | DRD2DRD4OPRM1DRD3KDM1A | |
| SCHEMBL731890 | 0.74 | KDM1A (0.35) | DRD2DRD4OPRM1DRD3KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138179-B2 | Spiro-imidazo compounds | NOVARTIS AG (CH) | 2012-03-20 | — | — | US | disclosed |