Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | DRD4 | P21917 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.31 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.30 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | EP300 | Q09472 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL731890 | 0.89 | KDM1A (0.35) | KDM1ADRD2DRD4OPRM1DRD3 | |
| SCHEMBL731027 | 0.85 | KDM1A (0.32) | KDM1ADRD2DRD4OPRM1DRD3 | |
| SCHEMBL731083 | 0.85 | DRD2 (0.33) | KDM1ADRD2DRD4OPRM1DRD3 | |
| SCHEMBL4045639 | 0.82 | KDM1A (0.34) | KDM1ADRD2DRD4OPRM1DRD3 | |
| SCHEMBL731222 | 0.81 | PGR (0.43) | KDM1ADRD2DRD4OPRM1DRD3 | |
| SCHEMBL733454 | 0.80 | KDM1A (0.39) | KDM1ADRD2DRD4OPRM1DRD3 | |
| SCHEMBL731436 | 0.77 | KDM1A (0.35) | KDM1ADRD2DRD4OPRM1DRD3 | |
| SCHEMBL731360 | 0.77 | DRD2 (0.33) | KDM1ADRD2DRD4OPRM1DRD3 | |
| SCHEMBL733341 | 0.76 | KDM1A (0.35) | KDM1ADRD2DRD4OPRM1DRD3 | |
| SCHEMBL733371 | 0.74 | KDM1A (0.31) | KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010540-B1 | SPIRO-IMIDAZO COMPOUNDS | NOVARTIS AG (CH) | 2012-12-05 | — | — | EP | disclosed |
| US-20090192145-A1 | Spiro-Imidazo Compounds | SPEEDEL EXPERIMENTA AG (CH) | 2009-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090192145-A1 | Spiro-Imidazo Compounds | REN, NR3C2, AGTR1 | KDM1A 3697/4885PTGDR2 541/4885DRD2 2874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.