Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | RXRA | P19793 | 3/20 | 0.44 |
| ▸ | RXRB | P28702 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SNCA | P37840 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | CD69 | Q07108 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7306860 | 0.86 | CYP2C19 (0.43) | CYP2C19NR1H4SMN1; SMN2L3MBTL1HTT | |
| SCHEMBL29368122 | 0.82 | EGFR (0.53) | CYP2C19NR1H4SMN1; SMN2RXRARXRB | |
| SCHEMBL3621461 | 0.81 | NR1H4 (0.67) | CYP2C19NR1H4SMN1; SMN2RXRARXRB | |
| SCHEMBL7844967 | 0.80 | CYP2C19 (0.52) | CYP2C19SMN1; SMN2L3MBTL1HTTALDH1A1 | |
| SCHEMBL7846219 | 0.78 | SNCA (0.56) | CYP2C19SMN1; SMN2L3MBTL1HTTALDH1A1 | |
| SCHEMBL3947553 | 0.76 | L3MBTL1 (0.63) | SMN1; SMN2L3MBTL1HTTKDM4EPTGDR2 | |
| SCHEMBL15613307 | 0.75 | ALDH1A1 (0.62) | CYP2C19SMN1; SMN2L3MBTL1HTTKDM4E | |
| SCHEMBL13757719 | 0.74 | CYP2C19 (0.74) | CYP2C19SMN1; SMN2RXRARXRBL3MBTL1 | |
| SCHEMBL8580573 | 0.74 | RXRA (0.71) | CYP2C19NR1H4SMN1; SMN2RXRARXRB | |
| SCHEMBL14076377 | 0.74 | RXRA (0.54) | CYP2C19NR1H4SMN1; SMN2RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0911333-B1 | Pyrazolo[4,3-d]pyrimidine derivatives and pharmaceutical compositions containing them | PFIZER (US) | 2002-04-10 | — | — | EP | disclosed |
| US-6235742-B1 | CARDIOVASCULAR DISORDERS; ANTIALLERGENS | PFIZER INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0911333-A1 | Pyrazolo[4,3-d]pyrimidine derivatives and pharmaceutical compositions containing them | PFIZER INC. (US) | 1999-04-28 | — | — | EP | disclosed |