Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 10/20 | 0.71 |
| ▸ | PPARG | P37231 | 9/20 | 0.71 |
| ▸ | PPARD | Q03181 | 2/20 | 0.60 |
| ▸ | ACE | P12821 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7331137 | 0.89 | PPARA (0.89) | PPARAPPARGPPARDACECYP1A2 | |
| SCHEMBL8538273 | 0.89 | PPARA (0.89) | PPARAPPARGPPARDACECYP1A2 | |
| SCHEMBL4422552 | 0.89 | PPARA (0.89) | PPARAPPARGPPARDACECYP1A2 | |
| SCHEMBL5695687 | 0.86 | PPARA (0.70) | PPARAPPARGPPARDACECYP1A2 | |
| SCHEMBL20661658 | 0.84 | REN (0.54) | PPARAPPARGACE | |
| SCHEMBL14975662 | 0.84 | REN (0.54) | PPARAPPARGACE | |
| SCHEMBL19033721 | 0.82 | CTSK (0.54) | PPARAPPARGPPARDALDH1A1 | |
| SCHEMBL29401779 | 0.81 | PPARG (0.63) | PPARAPPARGPPARDACEMAPT | |
| SCHEMBL8420238 | 0.81 | PPARG (0.66) | PPARAPPARGPPARDACE | |
| SCHEMBL3862832 | 0.79 | PPARG (0.61) | PPARAPPARGPPARDCYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5262436-A | Administering; enzyme inhibitor | SCHERING CORPORATION (US) | 1993-11-16 | — | — | US | disclosed |
| EP-0566157-A1 | Neutral metalloendopeptidase inhibitors in the treatment of hypertension | SCHERING CORPORATION (US) | 1993-10-20 | — | — | EP | disclosed |
| US-5061710-A | Atrial natriuretic factors | SCHERING CORPORATION (US) | 1991-10-29 | — | — | US | disclosed |
| US-4929641-A | DIURETICS, ANGIOTENSIN CONVERTING ENZYMES | SCHERING CORPORATION (US) | 1990-05-29 | — | — | US | disclosed |
| US-4801609-A | Mercapto-acylamino acid antihypertensives | SCHERING CORPORATION (US) | 1989-01-31 | — | — | US | disclosed |
| EP-0254032-A2 | Neutral metalloendopeptidase inhibitors in the treatment of hypertension | SCHERING CORPORATION (US) | 1988-01-27 | — | — | EP | disclosed |