Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CTSC | P53634 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7315141 | 1.00 | RAB9A (0.44) | RAB9ANPC1L3MBTL1HPGDALDH1A1 | |
| SCHEMBL9740119 | 0.77 | USP30 (0.44) | RAB9ANPC1L3MBTL1HPGDTSHR | |
| SCHEMBL7307699 | 0.77 | ATM (0.42) | L3MBTL1HPGDALDH1A1TSHRMEN1 | |
| SCHEMBL7307705 | 0.77 | ATM (0.42) | L3MBTL1HPGDALDH1A1TSHRMEN1 | |
| SCHEMBL9049032 | 0.69 | RAB9A (0.51) | RAB9ANPC1L3MBTL1HPGDALDH1A1 | |
| SCHEMBL7312785 | 0.69 | POLB (0.53) | RAB9ANPC1L3MBTL1HPGDALDH1A1 | |
| SCHEMBL1863278 | 0.67 | CPB2 (0.40) | CTSS | |
| SCHEMBL5065073 | 0.67 | CTSK (0.39) | CTSSATM | |
| SCHEMBL1862554 | 0.67 | CTSK (0.39) | CTSSATM | |
| SCHEMBL18916814 | 0.66 | ANPEP (0.33) | CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5459131-A | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1995-10-17 | — | — | US | disclosed |
| US-5104869-A | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1992-04-14 | — | — | US | disclosed |
| EP-0427939-A2 | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1991-05-22 | — | — | EP | disclosed |