SCHEMBL7315168

SCHEMBL7315168

COC(=O)c1cccc(CBr)c1NCS(=O)(=O)c1ccc(OC)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.46
MMP1 P03956 3/20 0.44
MMP9 P14780 3/20 0.44
MMP13 P45452 3/20 0.44
ADAM17 P78536 2/20 0.44
ALDH1A1 P00352 4/20 0.43
MAPT P10636 2/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
KDM4E B2RXH2 3/20 0.43
HPGD P15428 3/20 0.43
HSD17B10 Q99714 2/20 0.43
L3MBTL1 Q9Y468 2/20 0.43
USP2 O75604 1/20 0.43
TSHR P16473 1/20 0.43
KMT2A Q03164 3/20 0.42
POLB P06746 1/20 0.42
GRK2 P25098 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7554889 0.88 MMP1 (0.56) LMNAMMP1MMP9MMP13ADAM17
SCHEMBL7311620 0.85 FFAR4 (0.52) LMNAMMP1MMP9MMP13ADAM17
SCHEMBL7323224 0.81 MMP1 (0.57) LMNAMMP1MMP9MMP13ADAM17
SCHEMBL7315173 0.76 MMP9 (0.62) LMNAMMP1MMP9MMP13ADAM17
SCHEMBL7324177 0.76 FFAR4 (0.47) LMNAMMP1MMP9MMP13ADAM17
SCHEMBL7319417 0.75 MMP1 (0.50) LMNAMMP1MMP9MMP13ADAM17
SCHEMBL7323911 0.75 MMP1 (0.43) LMNAMMP1MMP9MMP13ADAM17
SCHEMBL7317816 0.75 POLB (0.41) LMNAMMP1MMP9MMP13ADAM17
SCHEMBL7317773 0.74 FFAR4 (0.53) LMNAMMP1MMP9MMP13ADAM17
SCHEMBL7322617 0.74 MMP1 (0.41) LMNAMMP1MMP9MMP13ADAM17

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0938471-B1 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS AMERICAN CYANAMID CO (US) 2001-12-12 EP disclosed
EP-0938471-A1 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS American Cyanamid Company (US) 1999-09-01 EP disclosed
US-5929097-A INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME AMERICAN CYANAMID COMPANY (US) 1999-07-27 US disclosed
WO-1998016503-A2 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS AMERICAN CYANAMID COMPANY (US) 1998-04-23 WO disclosed