Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 14/20 | 0.62 |
| ▸ | MMP13 | P45452 | 13/20 | 0.62 |
| ▸ | MMP1 | P03956 | 13/20 | 0.62 |
| ▸ | ADAM17 | P78536 | 10/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7311421 | 0.88 | MMP1 (0.81) | MMP9MMP13MMP1ADAM17KDM4E | |
| SCHEMBL7322996 | 0.84 | MMP9 (0.54) | MMP9MMP13MMP1ADAM17KDM4E | |
| SCHEMBL7311624 | 0.84 | CYP2C9 (0.60) | MMP9MMP13MMP1ADAM17KDM4E | |
| SCHEMBL7324037 | 0.82 | MMP9 (0.70) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL7323227 | 0.81 | MMP1 (0.82) | MMP9MMP13MMP1ADAM17KDM4E | |
| SCHEMBL27511019 | 0.77 | KEAP1 (0.57) | MMP9MMP13MMP1ADAM17CYP2C9 | |
| SCHEMBL7316361 | 0.77 | MMP9 (0.79) | MMP9MMP13MMP1ADAM17KEAP1 | |
| SCHEMBL7319166 | 0.77 | MMP9 (1.00) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL7315168 | 0.76 | LMNA (0.46) | MMP9MMP13MMP1ADAM17KDM4E | |
| SCHEMBL27569107 | 0.76 | KEAP1 (0.51) | MMP9MMP13MMP1ADAM17KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938471-B1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID CO (US) | 2001-12-12 | — | — | EP | disclosed |
| EP-0938471-A1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | American Cyanamid Company (US) | 1999-09-01 | — | — | EP | disclosed |
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |
| WO-1998016503-A2 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |