SCHEMBL7315207

SCHEMBL7315207

COC(=O)c1cccc(CN2CCCC2)c1NS(=O)(=O)c1ccc(OC)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.55
TCF4 P15884 1/20 0.50
CTNNB1 P35222 1/20 0.50
MMP1 P03956 2/20 0.49
MMP9 P14780 2/20 0.49
MMP13 P45452 2/20 0.49
ADAM17 P78536 2/20 0.49
SETD7 Q8WTS6 1/20 0.49
MEN1 O00255 1/20 0.48
KMT2A Q03164 1/20 0.48
ALDH1A1 P00352 5/20 0.47
SMN1; SMN2 Q16637 3/20 0.47
TP53 P04637 1/20 0.47
HPGD P15428 1/20 0.47
HTT P42858 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
KDM4E B2RXH2 1/20 0.47
GAA P10253 1/20 0.47
PKM P14618 1/20 0.47
MAPK1 P28482 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7313726 0.80 MMP1 (0.42) LMNAMMP1MMP9MMP13ADAM17
SCHEMBL7323224 0.79 MMP1 (0.57) LMNAMMP1MMP9MMP13ADAM17
SCHEMBL7315611 0.77 MMP9 (0.57) MMP1MMP9MMP13ADAM17
SCHEMBL7324979 0.77 LMNA (0.67) LMNATCF4CTNNB1ALDH1A1SMN1; SMN2
SCHEMBL5159892 0.77 FFAR4 (0.74) LMNATCF4CTNNB1ADAM17ALDH1A1
SCHEMBL7312674 0.76 MMP1 (0.54) MMP1MMP9MMP13ADAM17KDM4E
SCHEMBL7322570 0.76 LMNA (0.65) LMNATCF4CTNNB1MEN1KMT2A
SCHEMBL7312055 0.76 LMNA (0.65) LMNATCF4CTNNB1MEN1KMT2A
SCHEMBL6270957 0.76 GAA (0.56) LMNASETD7MEN1KMT2AALDH1A1
SCHEMBL28343653 0.75 KDM4E (0.60) LMNAMEN1KMT2AALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0938471-B1 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS AMERICAN CYANAMID CO (US) 2001-12-12 EP disclosed
EP-0938471-A1 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS American Cyanamid Company (US) 1999-09-01 EP disclosed
US-5929097-A INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME AMERICAN CYANAMID COMPANY (US) 1999-07-27 US disclosed
WO-1998016503-A2 THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS AMERICAN CYANAMID COMPANY (US) 1998-04-23 WO disclosed