Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 8/20 | 0.42 |
| ▸ | MMP9 | P14780 | 8/20 | 0.42 |
| ▸ | MMP13 | P45452 | 8/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 7/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | MMP3 | P08254 | 2/20 | 0.38 |
| ▸ | MMP8 | P22894 | 2/20 | 0.38 |
| ▸ | MMP14 | P50281 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316350 | 0.93 | MMP1 (0.42) | MMP1MMP9MMP13ADAM17KDM4E | |
| SCHEMBL7315174 | 0.92 | MMP9 (0.51) | MMP1MMP9MMP13ADAM17L3MBTL1 | |
| SCHEMBL7317521 | 0.87 | MMP13 (0.41) | MMP1MMP9MMP13ADAM17KDM4E | |
| SCHEMBL7322032 | 0.87 | MMP13 (0.40) | MMP1MMP9MMP13ADAM17KDM4E | |
| SCHEMBL7316579 | 0.86 | KDM4E (0.44) | MMP1MMP9MMP13ADAM17KDM4E | |
| SCHEMBL7322262 | 0.86 | LMNA (0.43) | MMP1MMP9MMP13ADAM17KDM4E | |
| SCHEMBL7316215 | 0.84 | MMP13 (0.41) | MMP1MMP9MMP13ADAM17KDM4E | |
| SCHEMBL7315207 | 0.80 | LMNA (0.55) | MMP1MMP9MMP13ADAM17KDM4E | |
| SCHEMBL7314645 | 0.80 | MMP1 (0.46) | MMP1MMP9MMP13ADAM17KDM4E | |
| SCHEMBL7324047 | 0.79 | GABRG2 (0.42) | MMP1MMP9MMP13ADAM17LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |