Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.78 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.78 |
| ▸ | HTT | P42858 | 2/20 | 0.78 |
| ▸ | LMNA | P02545 | 2/20 | 0.78 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.78 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.78 |
| ▸ | DRD2 | P14416 | 1/20 | 0.78 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.78 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.78 |
| ▸ | CNR1 | P21554 | 1/20 | 0.78 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.78 |
| ▸ | HTR2A | P28223 | 1/20 | 0.78 |
| ▸ | HTR2C | P28335 | 1/20 | 0.78 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.78 |
| ▸ | HRH1 | P35367 | 1/20 | 0.78 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.78 |
| ▸ | DRD3 | P35462 | 1/20 | 0.78 |
| ▸ | HTR2B | P41595 | 1/20 | 0.78 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.78 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10731346 | 0.97 | CHRM2 (0.74) | CHRM2OPRK1HTTLMNAADORA3 | |
| SCHEMBL1152274 | 0.93 | LMNA (0.91) | CHRM2OPRK1HTTLMNAADORA3 | |
| Hydrochloric Acid SCHEMBL7324923 | 0.92 | LMNA (0.89) | CHRM2OPRK1HTTLMNAADORA3 | |
| Lomerizine SCHEMBL29496366 | 0.88 | LMNA (1.00) | CHRM2OPRK1HTTLMNAADORA3 | |
| Lomerizine SCHEMBL79390 | 0.88 | LMNA (1.00) | CHRM2OPRK1HTTLMNAADORA3 | |
| SCHEMBL10494953 | 0.88 | MEN1 (0.63) | CHRM2OPRK1HTTLMNAADORA3 | |
| SCHEMBL7757458 | 0.87 | HTT (0.61) | CHRM2OPRK1HTTLMNAADORA3 | |
| Lomerizine SCHEMBL29439945 | 0.86 | LMNA (0.98) | CHRM2OPRK1HTTLMNAADORA3 | |
| Lomerizine SCHEMBL1153647 | 0.86 | LMNA (0.98) | CHRM2OPRK1HTTLMNAADORA3 | |
| Lomerizine SCHEMBL404179 | 0.86 | LMNA (0.98) | CHRM2OPRK1HTTLMNAADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0159566-A1 | Novel piperazine derivatives, processes for production thereof, and pharmaceutical compositions comprising said compounds as active ingredient | KANEBO, LTD. (JP) | 1985-10-30 | — | — | EP | disclosed |