Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Lomerizine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.98 |
| ▸ | OPRK1 known ✓ | P41145 | 2/20 | 0.98 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.98 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.98 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.98 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.98 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.98 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.98 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.98 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.98 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.98 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.98 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.98 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.98 |
| ▸ | CACNA1B known ✓ | Q00975 | 1/20 | 0.98 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.98 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.98 |
| ▸ | SCN5A known ✓ | Q14524 | 1/20 | 0.98 |
| ▸ | GHSR known ✓ | Q92847 | 1/20 | 0.98 |
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lomerizine SCHEMBL29439945 | 1.00 | LMNA (0.98) | LMNACHRM2OPRK1ADORA3CHRM1 | |
| Lomerizine SCHEMBL1153647 | 1.00 | LMNA (0.98) | LMNACHRM2OPRK1ADORA3CHRM1 | |
| Lomerizine SCHEMBL79390 | 0.99 | LMNA (1.00) | LMNACHRM2OPRK1ADORA3CHRM1 | |
| Lomerizine SCHEMBL29496366 | 0.99 | LMNA (1.00) | LMNACHRM2OPRK1ADORA3CHRM1 | |
| Lomerizine SCHEMBL1650277 | 0.96 | LMNA (0.95) | LMNACHRM2OPRK1ADORA3CHRM1 | |
| Hydrochloric Acid SCHEMBL7324923 | 0.96 | LMNA (0.89) | LMNACHRM2OPRK1ADORA3CHRM1 | |
| SCHEMBL1152274 | 0.94 | LMNA (0.91) | LMNACHRM2OPRK1ADORA3CHRM1 | |
| Lomerizine SCHEMBL10731133 | 0.90 | LMNA (0.82) | LMNACHRM2OPRK1ADORA3CHRM1 | |
| Lomerizine SCHEMBL10731150 | 0.90 | LMNA (0.82) | LMNACHRM2OPRK1ADORA3CHRM1 | |
| Hydrochloric Acid SCHEMBL28027560 | 0.90 | LMNA (0.78) | LMNACHRM2OPRK1ADORA3CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 388 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111991364-B | Lomerizine hydrochloride osmotic pump tablet and preparation method thereof | 四川省百草生物药业有限公司 | 2022-07-22 | — | — | CN | claimed |
| CN-111991364-A | Lomerizine hydrochloride osmotic pump tablet and preparation method thereof | 四川省百草生物药业有限公司 | 2020-11-27 | — | — | CN | claimed |
| CN-109666008-A | A kind of synthetic method of lomerizine hydrochloride | 辰欣药业股份有限公司 | 2019-04-23 | — | — | CN | claimed |
| CN-109580836-A | A kind of lomerizine hydrochloride raw material and detection method of the preparation in relation to substance | 辰欣药业股份有限公司 | 2019-04-05 | — | — | CN | claimed |
| CN-103601702-B | A kind of preparation method of lomerizine hydrochloride | 威海迪素制药有限公司 | 2018-04-17 | — | — | CN | claimed |
| US-20170304388-A1 | NEW INDICATION OF CARDIOVASCULAR DRUGS FOR PREPARATION OF CANCER INHIBITION PHARMACEUTICAL COMPOSITION | LAUNX BIOMEDICAL CO., LTD. (TW) | 2017-10-26 | — | — | US | claimed |
| CN-106667938-A | Lomerizine hydrochloride tablets and preparation method thereof | 辰欣药业股份有限公司 | 2017-05-17 | — | — | CN | claimed |
| CN-103211801-B | One is rapidly-soluble membrane and preparation method thereof in the oral cavity | Chongqing Institute of Bench-to-Bed Bioengineering Technology Co.,Ltd. (CN) | 2016-02-03 | — | — | CN | claimed |
| CN-102936233-B | A kind of 1-(two (4-fluorophenyl) methyl)-4-(2,3,4-2,4,5-trimethoxyphenyl) piperazine dihydrochloride crystal formation | Ge changle (CN) | 2016-01-20 | — | — | CN | claimed |
| CN-105175359-A | Lomerizine Hydrochloride isomeride and preparation method therefor | SICHUAN BAICAO BIOLOG PHARMACEUTICAL CO LTD | 2015-12-23 | — | — | CN | claimed |
| CN-103462919-A | Lomerizine hydrochloride tablet and preparation method thereof | NANJING ZHENGLIANG MED TECH CO | 2013-12-25 | — | — | CN | claimed |
| CN-103211801-A | Film agent quickly dissolved in oral cavity and preparation method thereof | SUZHOU RENBEN PHARMACEUTICAL CO LTD | 2013-07-24 | — | — | CN | claimed |
| CN-102319227-B | Lomerizine hydrochloride osmotic pump tablet and preparation method thereof | NANJING ZENKOM PHARMACEUTICAL CO LTD | 2013-04-03 | — | — | CN | claimed |
| CN-102898403-A | Method for preparing novel crystal form of 1-(bi(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxyphenyl)piperazine dihydrochloride | Ge changle | 2013-01-30 | — | — | CN | claimed |
| CN-102319227-A | Lomerizine hydrochloride osmotic pump tablet and preparation method thereof | NANJING ZENKOM PHARMACEUTICAL CO LTD | 2012-01-18 | — | — | CN | claimed |
| CN-1988896-A | Use of compounds active on the sigma receptor for the treatment of mechanical allodynia | ESTEVE LABOR DR (ES) | 2007-06-27 | — | — | CN | claimed |
| WO-2006138012-A1 | P450 SUBSTRATES AND METHODS RELATED THERETO | CERES INC. (US) | 2006-12-28 | — | — | WO | claimed |
| CN-1628668-A | Lomerizine hydrochloride orally disintegrating tablet and preparation method thereof | NANJING GOLDENEANGLE MEDICINE (CN) | 2005-06-22 | — | — | CN | claimed |
| CN-1589797-A | Lomeilizine hydrochloride oral cavity disintegration tablet and its preparation method | FAN MINHUA (CN) | 2005-03-09 | — | — | CN | claimed |
| CN-1562988-A | Method for synthesizing Lomerizine Hydrochlortde | CHANGAO MEDICINES TECH CO LTD (CN) | 2005-01-12 | — | — | CN | claimed |