Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.76 |
| ▸ | LMNA | P02545 | 1/20 | 0.76 |
| ▸ | TP53 | P04637 | 1/20 | 0.76 |
| ▸ | MAPT | P10636 | 1/20 | 0.76 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.71 |
| ▸ | MGLL | Q99685 | 9/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | FPR2 | P25090 | 1/20 | 0.59 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.59 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7315799 | 1.00 | L3MBTL1 (0.76) | L3MBTL1LMNATP53MAPTNPSR1 | |
| SCHEMBL13897436 | 0.85 | NPSR1 (0.59) | L3MBTL1LMNATP53MAPTNPSR1 | |
| SCHEMBL3595154 | 0.84 | NPSR1 (0.70) | L3MBTL1LMNATP53MAPTNPSR1 | |
| SCHEMBL4671553 | 0.82 | L3MBTL1 (0.54) | L3MBTL1LMNATP53MAPTNPSR1 | |
| SCHEMBL3391998 | 0.81 | MGLL (0.69) | L3MBTL1LMNATP53MAPTMGLL | |
| SCHEMBL13657578 | 0.79 | MGLL (0.71) | L3MBTL1LMNATP53MAPTMGLL | |
| (4-Chlorophenyl)(Cyclopropyl)Methanone SCHEMBL392801 | 0.78 | MGLL (0.68) | L3MBTL1LMNATP53MAPTMGLL | |
| SCHEMBL14154609 | 0.78 | MGLL (0.69) | L3MBTL1LMNATP53MAPTMGLL | |
| SCHEMBL6209685 | 0.77 | ALDH1A1 (0.70) | L3MBTL1LMNATP53MAPTMGLL | |
| SCHEMBL4674725 | 0.77 | LMNA (0.61) | L3MBTL1LMNATP53MAPTMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376506-B1 | REACTING SULFAMOYL OXAZOLIDONE WITH (1,2,3,4)-TETRAHYDRO-BETA-CARBOLINE TO FORM INHIBITOR; USED TO TREAT ARTHRITIS, OSTEOPOROSIS, PERIODONTAL DISEASE, CARDIOVASCULAR DISEASES, MULTIPLE SCLEROSIS, AND TUMORS | SYNTEX (U.S.A.) LLC | 2002-04-23 | — | — | US | disclosed |
| US-6143744-A | Sulfamide-metalloprotease inhibitors | SYNTEX (U.S.A.) INC. (US) | 2000-11-07 | — | — | US | disclosed |
| US-6130220-A | ENZYME INHIBITORS | SYNTEX (USA) INC. (US) | 2000-10-10 | — | — | US | disclosed |
| US-5998412-A | ANTIARTHRITIC AGENTS; OSTEOPOROSIS | SYNTEX (U.S.A.) INC. (US) | 1999-12-07 | — | — | US | disclosed |