Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 7/20 | 0.67 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7315942 | 1.00 | HDAC1 (0.67) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL7322092 | 1.00 | HDAC1 (0.67) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL9542310 | 0.92 | NPC1 (0.56) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL9790512 | 0.92 | NPC1 (0.56) | HDAC1HDAC8HDAC6HDAC2HDAC3 | |
| SCHEMBL7316244 | 0.90 | HDAC1 (0.53) | HDAC1HDAC8HDAC6HDAC2MAOB | |
| SCHEMBL7316237 | 0.90 | HDAC1 (0.53) | HDAC1HDAC8HDAC6HDAC2MAOB | |
| SCHEMBL7319093 | 0.90 | HDAC1 (0.53) | HDAC1HDAC8HDAC6HDAC2MAOB | |
| SCHEMBL9790511 | 0.88 | LMNA (0.59) | HDAC1HDAC6MAOBALDH1A1LMNA | |
| SCHEMBL9790455 | 0.88 | LMNA (0.56) | HDAC1MAOBALDH1A1LMNAHPGD | |
| SCHEMBL9790517 | 0.88 | RAB9A (0.54) | HDAC1MAOBALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6034096-A | Compounds with anti-inflammatory and immunosuppressive activities | ITALFARMACO S.P.A. (IT) | 2000-03-07 | — | — | US | claimed |
| EP-0901465-B1 | COMPOUNDS WITH ANTI-INFLAMMATORY AND IMMUNOSUPPRESSIVE ACTIVITIES | ITALFARMACO SPA (IT) | 2000-09-27 | — | — | EP | disclosed |
| US-6034096-A | Compounds with anti-inflammatory and immunosuppressive activities | ITALFARMACO S.P.A. (IT) | 2000-03-07 | — | — | US | disclosed |