Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 4/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 5/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3596443 | 0.73 | FLT3 (0.64) | FLT3KDR | |
| Formic Acid SCHEMBL73159 | 0.71 | IRAK4 (0.47) | MIFKDRCDK1CDK4CDK2 | |
| SCHEMBL18003003 | 0.69 | MIF (0.56) | MIFFLT3PIK3CAPRMT5WDR77 | |
| SCHEMBL3585409 | 0.69 | FLT3 (0.54) | FLT3KDRGABRG2GABRB3GABRA3 | |
| SCHEMBL73961 | 0.69 | IRAK4 (0.52) | MIFFLT3PIK3CAKDRCDK1 | |
| SCHEMBL2650330 | 0.65 | FLT3 (0.74) | MIFFLT3PIK3CAKDRIRAK4 | |
| SCHEMBL73445 | 0.65 | MIF (0.60) | MIFFLT3PIK3CAPRMT5WDR77 | |
| SCHEMBL73247 | 0.65 | BACE1 (0.62) | MIFFLT3PIK3CAKDRCDK2 | |
| SCHEMBL29109646 | 0.65 | FLT3 (0.69) | MIFFLT3PIK3CAPRMT5WDR77 | |
| SCHEMBL14138786 | 0.65 | MIF (0.60) | MIFFLT3PIK3CAPRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8131527-B1 | FGFR pharmacophore compounds | ASTEX THERAPEUTICS LTD. (GB) | 2012-03-06 | — | — | US | disclosed |