Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.60 |
| ▸ | MMP13 | P45452 | 2/20 | 0.60 |
| ▸ | MMP9 | P14780 | 1/20 | 0.60 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.60 |
| ▸ | LTA4H | P09960 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7348743 | 0.92 | MMP13 (0.70) | MMP1MMP13MMP9ADAM17LTA4H | |
| SCHEMBL7318143 | 0.89 | MMP1 (0.56) | MMP1MMP13MMP9ADAM17LTA4H | |
| SCHEMBL7320048 | 0.82 | MMP1 (0.84) | MMP1MMP13MMP9ADAM17LTA4H | |
| SCHEMBL7316213 | 0.80 | MMP1 (0.57) | MMP1MMP13MMP9ADAM17ALDH1A1 | |
| SCHEMBL7355486 | 0.75 | MMP9 (1.00) | MMP1MMP13MMP9ADAM17 | |
| SCHEMBL7348749 | 0.75 | MMP9 (1.00) | MMP1MMP13MMP9ADAM17 | |
| SCHEMBL7315611 | 0.75 | MMP9 (0.57) | MMP1MMP13MMP9ADAM17MMP3 | |
| SCHEMBL7318146 | 0.73 | MMP1 (0.78) | MMP1MMP13MMP9ADAM17ALDH1A1 | |
| SCHEMBL7554630 | 0.73 | MMP1 (0.78) | MMP1MMP13MMP9ADAM17ALDH1A1 | |
| SCHEMBL7323224 | 0.73 | MMP1 (0.57) | MMP1MMP13MMP9ADAM17CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |