Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 11/20 | 0.41 |
| ▸ | CTSB | P07858 | 5/20 | 0.41 |
| ▸ | CTSL | P07711 | 5/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | REN | P00797 | 5/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9641169 | 1.00 | CTSS (0.41) | CTSSCTSBCTSLCTSKREN | |
| SCHEMBL9642305 | 0.84 | METAP2 (0.41) | CTSSCTSBCTSLCTSKCNR2 | |
| SCHEMBL7324654 | 0.84 | METAP2 (0.41) | CTSSCTSBCTSLCTSKCNR2 | |
| SCHEMBL7382471 | 0.84 | CTSS (0.39) | CTSSCTSBCTSLCTSKREN | |
| SCHEMBL7359101 | 0.84 | CTSS (0.39) | CTSSCTSBCTSLCTSKCNR2 | |
| SCHEMBL7359089 | 0.84 | CTSS (0.39) | CTSSCTSBCTSLCTSKCNR2 | |
| SCHEMBL7367978 | 0.80 | CTSS (0.37) | CTSSCTSBCTSLCTSKREN | |
| SCHEMBL9642437 | 0.79 | REN (0.48) | REN | |
| SCHEMBL7323447 | 0.78 | REN (0.39) | REN | |
| SCHEMBL7321559 | 0.78 | CTSS (0.36) | CTSSCTSBCTSLCTSKREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0231919-B1 | N-HETEROCYCLIC ALCOHOL RENIN INHIBITORS | E.R. Squibb & Sons, Inc. (US) | 1993-01-20 | — | — | EP | disclosed |
| US-4981843-A | HYPOTENSIVE | E. R. SQUIBB & SONS, INC. (US) | 1991-01-01 | — | — | US | disclosed |
| US-4885292-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1989-12-05 | — | — | US | disclosed |
| EP-0231919-A2 | N-Heterocyclic alcohol renin inhibitors | E.R. Squibb & Sons, Inc. (US) | 1987-08-12 | — | — | EP | disclosed |