Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 8/20 | 0.39 |
| ▸ | CTSB | P07858 | 4/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 4/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.35 |
| ▸ | USP19 | O94966 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7359089 | 1.00 | CTSS (0.39) | CTSSCTSBCTSKCTSLATM | |
| SCHEMBL9642305 | 0.85 | METAP2 (0.41) | CTSSCTSBCTSKCTSLOPRD1 | |
| SCHEMBL7324654 | 0.85 | METAP2 (0.41) | CTSSCTSBCTSKCTSLOPRD1 | |
| SCHEMBL7316845 | 0.84 | CTSS (0.41) | CTSSCTSBCTSKCTSLCNR2 | |
| SCHEMBL9641169 | 0.84 | CTSS (0.41) | CTSSCTSBCTSKCTSLCNR2 | |
| SCHEMBL7366123 | 0.79 | CTSS (0.33) | CTSSCTSBCTSKCTSLLNPEP | |
| SCHEMBL7320023 | 0.79 | CTSS (0.32) | CTSSCTSBCTSKCTSLLNPEP | |
| SCHEMBL7320027 | 0.79 | CTSS (0.34) | CTSSCTSBCTSKCTSL | |
| SCHEMBL7320165 | 0.77 | REN (0.40) | CTSSCTSBCTSKCTSL | |
| SCHEMBL7320151 | 0.77 | REN (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0231919-B1 | N-HETEROCYCLIC ALCOHOL RENIN INHIBITORS | E.R. Squibb & Sons, Inc. (US) | 1993-01-20 | — | — | EP | disclosed |