Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.32 |
| ▸ | TUBB | P07437 | 1/20 | 0.32 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.32 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.32 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.32 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.32 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.32 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.32 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.32 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.32 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.32 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5370189 | 0.81 | ALDH1A1 (0.44) | TDP1ALDH1A1TSHRPTGS2AR | |
| SCHEMBL7317610 | 0.81 | AR (0.33) | ARSLC6A4TUBB4ATUBBTUBA3C | |
| SCHEMBL31351861 | 0.79 | SLC6A4 (0.42) | ARSLC6A4KDM4EHSD17B10 | |
| SCHEMBL5950486 | 0.78 | TP53 (0.54) | TP53TDP1ALDH1A1TSHRPTGS2 | |
| SCHEMBL19289354 | 0.75 | ALDH1A1 (0.50) | TP53TDP1ALDH1A1TSHRAR | |
| SCHEMBL7550633 | 0.73 | TDP1 (0.48) | TP53TDP1ALDH1A1TSHRPTGS2 | |
| SCHEMBL28687409 | 0.72 | ALDH1A1 (0.52) | TP53TDP1ALDH1A1TSHRPTGS2 | |
| SCHEMBL10294043 | 0.71 | ACHE (0.48) | TP53TDP1ALDH1A1TSHRAR | |
| SCHEMBL21881 | 0.71 | TDP1 (0.67) | TP53TDP1ALDH1A1TSHRPTGS2 | |
| SCHEMBL10294034 | 0.69 | ACHE (0.43) | TP53ALDH1A1ARSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4845100-A | WITH HYPOTENSIVE AND ANTIINFLAMMATORY ACTIVITY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1989-07-04 | — | — | US | disclosed |
| EP-0202760-A2 | Carbostyril derivatives and salts thereof, processes for preparing the same and cardiotonic composition containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-11-26 | — | — | EP | disclosed |