Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 11/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 9/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.43 |
| ▸ | GRN | P28799 | 1/20 | 0.40 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.40 |
| ▸ | GCK | P35557 | 2/20 | 0.40 |
| ▸ | RBBP9 | O75884 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7317703 | 1.00 | CTSK (0.61) | CTSKPOLBEPHX2F2PRSS1 | |
| SCHEMBL8337500 | 0.79 | CTSK (0.53) | CTSKPOLBEPHX2GRNSORT1 | |
| SCHEMBL8337771 | 0.78 | CTSK (0.51) | CTSKPOLBEPHX2GRNSORT1 | |
| SCHEMBL7316693 | 0.74 | POLB (0.43) | CTSKPOLBEPHX2GCK | |
| SCHEMBL7316703 | 0.74 | POLB (0.43) | CTSKPOLBEPHX2GCK | |
| SCHEMBL3306590 | 0.69 | ALDH1A1 (0.50) | CTSKRBBP9 | |
| SCHEMBL17661712 | 0.69 | CTSK (0.60) | CTSKF2PRSS1RBBP9 | |
| SCHEMBL17661702 | 0.69 | CTSK (0.60) | CTSKF2PRSS1RBBP9 | |
| SCHEMBL17646249 | 0.69 | CTSB (0.53) | CTSKF2PRSS1 | |
| SCHEMBL17665987 | 0.69 | CTSB (0.53) | CTSKF2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0231919-B1 | N-HETEROCYCLIC ALCOHOL RENIN INHIBITORS | E.R. Squibb & Sons, Inc. (US) | 1993-01-20 | — | — | EP | disclosed |
| US-4981843-A | HYPOTENSIVE | E. R. SQUIBB & SONS, INC. (US) | 1991-01-01 | — | — | US | disclosed |
| US-4885292-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1989-12-05 | — | — | US | disclosed |
| EP-0337295-A2 | Renin-inhibiting N-heterocyclic dipeptides | E.R. Squibb & Sons, Inc. (US) | 1989-10-18 | — | — | EP | disclosed |