Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 11/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7314523 | 0.72 | NAMPT (0.55) | NAMPTALDH1A1SMN1; SMN2MMP1MMP9 | |
| SCHEMBL7322218 | 0.72 | NAMPT (0.55) | NAMPTALDH1A1SMN1; SMN2MMP1MMP9 | |
| SCHEMBL7506961 | 0.72 | MMP9 (0.68) | MMP1MMP9MMP13ADAM17 | |
| SCHEMBL7318036 | 0.71 | NAMPT (0.46) | NAMPTALDH1A1MMP1MMP9MMP13 | |
| SCHEMBL7445098 | 0.71 | MMP9 (0.64) | MMP1MMP9MMP13ADAM17 | |
| SCHEMBL7444538 | 0.71 | MMP13 (0.79) | MMP1MMP9MMP13ADAM17 | |
| SCHEMBL27529949 | 0.70 | ALDH1A1 (0.57) | ALDH1A1KDM4EMMP1MMP9MMP13 | |
| SCHEMBL7325342 | 0.70 | NAMPT (0.56) | NAMPTALDH1A1SMN1; SMN2MMP1MMP9 | |
| SCHEMBL7319361 | 0.69 | MMP9 (0.56) | NAMPTMMP1MMP9MMP13ADAM17 | |
| SCHEMBL163178 | 0.68 | NAMPT (1.00) | NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |