SCHEMBL7318116

SCHEMBL7318116

COc1ccc(-c2ccc(C(=O)NN)cc2)cc1

nearest known ligand 0.89

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 4/20 0.89
CA2 P00918 4/20 0.89
ALDH1A1 P00352 5/20 0.69
MAPT P10636 3/20 0.69
HTT P42858 1/20 0.69
PLK1 P53350 1/20 0.61
NPC1 O15118 4/20 0.59
RAB9A P51151 4/20 0.59
POLB P06746 2/20 0.58
KDM4E B2RXH2 1/20 0.58
GAA P10253 1/20 0.58
TP53 P04637 1/20 0.58
ALOX15 P16050 1/20 0.58
SMN1; SMN2 Q16637 1/20 0.58
KMT2A Q03164 1/20 0.56
CTDSP1 Q9GZU7 1/20 0.56
LMNA P02545 3/20 0.56
L3MBTL1 Q9Y468 1/20 0.56
PARP1 P09874 1/20 0.55
PARP10 Q53GL7 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL407188 0.94 CA1 (1.00) CA1CA2ALDH1A1MAPTHTT
Hydrochloric Acid SCHEMBL4259929 0.92 CA1 (0.96) CA1CA2ALDH1A1MAPTHTT
SCHEMBL752600 0.84 MPO (0.70) CA1CA2ALDH1A1MAPTHTT
SCHEMBL4338297 0.83 MAPT (0.89) CA1CA2ALDH1A1MAPTRAB9A
SCHEMBL14722006 0.83 PLK1 (0.89) CA1CA2ALDH1A1MAPTHTT
SCHEMBL23484773 0.83 PLK1 (0.89) CA1CA2ALDH1A1MAPTHTT
SCHEMBL6375604 0.83 CA1 (0.62) CA1CA2ALDH1A1MAPTHTT
SCHEMBL9377865 0.83 CA1 (0.77) CA1CA2ALDH1A1MAPTHTT
SCHEMBL3201438 0.82 ALDH1A1 (1.00) CA1CA2ALDH1A1MAPTHTT
SCHEMBL25003795 0.81 MAP4K4 (0.63) CA1CA2ALDH1A1MAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017064490-A1 CROSS-LINKABLE CHARGE TRANSPORT MATERIALS LOMOX LIMITED (GB) 2017-04-20 WO disclosed
US-6232290-B1 FUNGICIDES AGAINST PNEUMOCYSTIS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-05-15 US disclosed
EP-1053247-A1 ANTIFUNGAL CYCLOHEXAPEPTIDES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-11-22 EP disclosed
WO-1999040108-A1 NEW COMPOUND FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-08-12 WO disclosed