Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7309339 | 0.84 | CYP2C19 (0.44) | HSD11B1CYP2C19HIF1AMAPTALDH1A1 | |
| SCHEMBL7315311 | 0.82 | MAPT (0.43) | HSD11B1CYP2C19HIF1AMAPTALDH1A1 | |
| SCHEMBL7311695 | 0.80 | HSD11B1 (0.38) | HSD11B1NR1I2CA12CA7CA9 | |
| SCHEMBL21798314 | 0.76 | MEN1 (0.36) | CA12CA9CA14MAPTTSHR | |
| SCHEMBL10176111 | 0.75 | TSHR (0.43) | NR1I2CA12CA7CA9CA14 | |
| SCHEMBL7304270 | 0.74 | KCNN4 (0.43) | KCNN4HSD11B1CA12CA7CA9 | |
| SCHEMBL7308150 | 0.72 | KCNA5 (0.44) | CA12CA7CA9CA14CYP2C19 | |
| SCHEMBL7309475 | 0.71 | MMP3 (0.60) | CA12CA7CA9CA14ALDH1A1 | |
| SCHEMBL4543902 | 0.67 | TSHR (0.42) | CA12CA7CA9CA14MAPT | |
| SCHEMBL602 | 0.67 | HSD11B1 (0.59) | HSD11B1TP53MAPTALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0931788-B1 | Metalloprotease inhibitors | PFIZER LTD (GB) | 2002-11-06 | — | — | EP | disclosed |
| US-6090852-A | MATRIX METALLOPROTEASE INHIBITOR | PFIZER INC (US) | 2000-07-18 | — | — | US | disclosed |
| EP-0931788-A2 | Metalloprotease inhibitors | Pfizer Limited (GB) | 1999-07-28 | — | — | EP | disclosed |