Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 9/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.46 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.46 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.46 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9501260 | 0.83 | ADORA3 (0.57) | CACNA1BADORA3CACNA1FCACNA1DCACNA1S | |
| SCHEMBL7419122 | 0.80 | ADORA3 (0.53) | CACNA1BADORA3CACNA1FCACNA1DCACNA1S | |
| SCHEMBL7316147 | 0.80 | ADORA3 (0.53) | CACNA1BADORA3CACNA1FCACNA1DCACNA1S | |
| Hydrochloric Acid SCHEMBL7464705 | 0.80 | CACNA1B (0.47) | CACNA1BADORA3CACNA1FCACNA1DCACNA1S | |
| SCHEMBL7471880 | 0.78 | ADORA3 (0.51) | CACNA1BADORA3CACNA1FCACNA1DCACNA1S | |
| SCHEMBL7350256 | 0.78 | CACNA1B (0.57) | CACNA1BADORA3CACNA1FCACNA1DCACNA1S | |
| SCHEMBL9669318 | 0.78 | ADORA3 (0.50) | CACNA1BADORA3CACNA1FCACNA1DCACNA1S | |
| SCHEMBL7267420 | 0.77 | CACNA1B (0.68) | CACNA1BADORA3 | |
| SCHEMBL7318265 | 0.77 | CACNA1B (0.51) | CACNA1BADORA3CACNA1FCACNA1DCACNA1S | |
| SCHEMBL7322259 | 0.76 | CACNA1B (0.53) | CACNA1BADORA3CACNA1FCACNA1DCACNA1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0271059-B1 | 2-Methylthiomethyl-dihydropyridines, a process for their preparation and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM ITALIA (IT) | 1993-10-20 | — | — | EP | claimed |
| EP-0271059-A1 | 2-Methylthiomethyl-dihydropyridines, a process for their preparation and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1988-06-15 | — | — | EP | claimed |
| EP-0271059-B1 | 2-Methylthiomethyl-dihydropyridines, a process for their preparation and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM ITALIA (IT) | 1993-10-20 | — | — | EP | disclosed |
| US-4971984-A | Cardiovascular disorders, hypotensive agints | BEEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) | 1990-11-20 | — | — | US | disclosed |
| EP-0271059-A1 | 2-Methylthiomethyl-dihydropyridines, a process for their preparation and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1988-06-15 | — | — | EP | disclosed |