SCHEMBL9501260

SCHEMBL9501260

CCOC(=O)C1=C(CSCC)NC(C)=C(C(=O)OC)C1c1cccc(Cl)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 3/20 0.57
HIF1A Q16665 5/20 0.56
CYP2C9 P11712 5/20 0.56
MEN1 O00255 4/20 0.56
CYP1A2 P05177 4/20 0.56
CYP3A4 P08684 4/20 0.56
CYP2C19 P33261 4/20 0.56
KMT2A Q03164 4/20 0.56
MAPT P10636 3/20 0.56
LMNA P02545 2/20 0.56
CYP2D6 P10635 2/20 0.56
TSHR P16473 2/20 0.56
NFKB1 P19838 2/20 0.56
THPO P40225 2/20 0.56
POLB P06746 1/20 0.56
MAPK1 P28482 1/20 0.56
GPR55 Q9Y2T6 1/20 0.56
KDM4E B2RXH2 2/20 0.52
HSD17B10 Q99714 2/20 0.52
ALDH1A1 P00352 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7419122 0.92 ADORA3 (0.53) ADORA3HIF1ACYP2C9MEN1CYP1A2
SCHEMBL7471880 0.90 ADORA3 (0.51) ADORA3HIF1ACYP2C9MEN1CYP1A2
SCHEMBL9669318 0.89 ADORA3 (0.50) ADORA3HIF1ACYP2C9MEN1CYP1A2
SCHEMBL7318265 0.89 CACNA1B (0.51) ADORA3HIF1ACYP2C9MEN1CYP1A2
SCHEMBL9502243 0.88 ADORA3 (0.73) ADORA3HIF1ACYP2C9MEN1CYP1A2
SCHEMBL7316147 0.88 ADORA3 (0.53) ADORA3HIF1ACYP2C9MEN1CYP1A2
SCHEMBL7350256 0.86 CACNA1B (0.57) ADORA3HIF1ACYP2C9MEN1CYP1A2
SCHEMBL9808332 0.85 ABCC1 (0.48) ADORA3HIF1ACYP2C9MEN1CYP1A2
SCHEMBL7368873 0.85 ADORA3 (0.49) ADORA3HIF1ACYP2C9MEN1CYP1A2
SCHEMBL7322259 0.84 CACNA1B (0.53) ADORA3HIF1ACYP2C9MEN1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0458823-B1 A PROCESS FOR PREPARATION OF ENANTIOMERICALLY PURE POLYSUBSTITUTED 1,4-DIHYDROPYRIDINES BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1993-10-13 EP disclosed
US-5245039-A PROCESS FOR PREPARATION OF ENANTIOMERICALLY PURE POLYSUBSTITUTED 1,4-DIHYDROPYRIDINES BOEHRINGER MANNHEIM ITALIA (IT) 1993-09-14 US disclosed
WO-1990009376-A1 A PROCESS FOR PREPARATION OF ENANTIOMERICALLY PURE POLYSUBSTITUTED 1,4-DIHYDROPYRIDINES BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1990-08-23 WO disclosed
EP-0383320-A1 A process for preparation of enantiomerically pure polysubstituted 1,4-dihydropyridines BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1990-08-22 EP disclosed