Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE known ✓ | P12821 | 12/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364696 | 0.95 | ACE (0.44) | SMN1; SMN2ACELMNAABCB11MEN1 | |
| SCHEMBL9394613 | 0.84 | ACE (0.40) | ACEALDH1A1 | |
| SCHEMBL7266941 | 0.83 | ACE (0.42) | ACELMNAPOLBALDH1A1 | |
| SCHEMBL8715043 | 0.74 | ACE (0.49) | SMN1; SMN2ACELMNAABCB11MEN1 | |
| SCHEMBL5551908 | 0.74 | DPP8 (0.40) | ACE | |
| SCHEMBL8568423 | 0.71 | ACE (0.45) | SMN1; SMN2ACELMNAMEN1KMT2A | |
| SCHEMBL10696084 | 0.71 | ACE (0.45) | SMN1; SMN2ACELMNAMEN1KMT2A | |
| SCHEMBL10883512 | 0.71 | DPP7 (0.39) | ACE | |
| SCHEMBL649164 | 0.71 | DPP8 (0.43) | ACE | |
| SCHEMBL5552493 | 0.71 | DPP8 (0.43) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006511-A | Treating hypertension, congestive heart failure | MERCK & CO., INC. (US) | 1991-04-09 | — | — | US | disclosed |
| EP-0156318-A2 | C-terminal amide cyclic renin inhibitors containing peptide isosteres | MERCK & CO. INC. (US) | 1985-10-02 | — | — | EP | disclosed |