Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 7/20 | 0.79 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7308033 | 0.88 | ECE1 (1.00) | ECE1GAARECQLGFERMAPT | |
| SCHEMBL7321910 | 0.87 | ECE1 (0.60) | ECE1MAPTNPC1HPGDTSHR | |
| SCHEMBL7321772 | 0.85 | ECE1 (0.82) | ECE1MAPTHPGDTSHRLMNA | |
| SCHEMBL7322763 | 0.80 | ECE1 (0.79) | ECE1HPGDTSHRSMN1; SMN2KDM4E | |
| SCHEMBL7311429 | 0.79 | ECE1 (0.83) | ECE1GFERMAPTHPGDTSHR | |
| SCHEMBL7322148 | 0.75 | ECE1 (0.77) | ECE1NPC1SMN1; SMN2MEN1RAB9A | |
| SCHEMBL7317687 | 0.75 | ECE1 (1.00) | ECE1MAPTHPGDTSHRLMNA | |
| SCHEMBL21547855 | 0.74 | GAA (0.63) | ECE1GAARECQLGFERMAPT | |
| SCHEMBL496467 | 0.70 | MAOA (0.50) | ECE1GAAMAPTNPC1SMN1; SMN2 | |
| SCHEMBL16724446 | 0.70 | POLB (0.45) | ECE1GAARECQLMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5891892-A | Small molecule biaryl compounds as inhibitors of endothelin converting enzyme | WARNER-LAMBERT COMPANY (US) | 1999-04-06 | — | — | US | disclosed |