Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 8/20 | 0.82 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7317687 | 0.90 | ECE1 (1.00) | ECE1HPGDTSHRALDH1A1ALOX15 | |
| SCHEMBL7321910 | 0.85 | ECE1 (0.60) | ECE1HPGDTSHRALDH1A1HSD17B10 | |
| SCHEMBL7318992 | 0.85 | ECE1 (0.79) | ECE1HPGDTSHRALDH1A1ALOX15 | |
| SCHEMBL7322763 | 0.78 | ECE1 (0.79) | ECE1HPGDTSHRMAPK1HSD17B10 | |
| SCHEMBL7311429 | 0.77 | ECE1 (0.83) | ECE1HPGDTSHRKDM4EMAPT | |
| SCHEMBL7322148 | 0.73 | ECE1 (0.77) | ECE1ALDH1A1ALOX15HSD17B10KDM4E | |
| SCHEMBL7308033 | 0.73 | ECE1 (1.00) | ECE1ALOX15KDM4EMAPTHTT | |
| SCHEMBL12852563 | 0.72 | MAOA (0.55) | ECE1HPGDTSHRMAPK1HSD17B10 | |
| SCHEMBL7321778 | 0.70 | ECE1 (0.43) | ECE1HPGDTSHRMAPK1HSD17B10 | |
| SCHEMBL16724446 | 0.68 | POLB (0.45) | ECE1HPGDTSHRALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5891892-A | Small molecule biaryl compounds as inhibitors of endothelin converting enzyme | WARNER-LAMBERT COMPANY (US) | 1999-04-06 | — | — | US | disclosed |