Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 18/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10448000 | 0.85 | REN (0.57) | RENCTSBCTSK | |
| SCHEMBL7319508 | 0.84 | CTSD (0.37) | RENCTSBCTSK | |
| SCHEMBL7319509 | 0.84 | CTSD (0.37) | RENCTSBCTSK | |
| SCHEMBL10448583 | 0.76 | HRH3 (0.45) | RENCTSBCTSK | |
| SCHEMBL10659894 | 0.74 | REN (0.78) | REN | |
| SCHEMBL10657717 | 0.72 | REN (0.72) | REN | |
| SCHEMBL10656924 | 0.72 | ENPEP (0.44) | — | |
| SCHEMBL10656917 | 0.72 | ENPEP (0.44) | — | |
| SCHEMBL13912236 | 0.70 | HTR1D (0.49) | — | |
| SCHEMBL10447999 | 0.68 | REN (0.42) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0437508-A1 | NON-PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1991-07-24 | — | — | EP | disclosed |
| WO-1990003971-A1 | NON-PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1990-04-19 | — | — | WO | disclosed |