Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 12/20 | 0.37 |
| ▸ | REN | P00797 | 3/20 | 0.35 |
| ▸ | IL1RN | P18510 | 3/20 | 0.34 |
| ▸ | ERAP2 | Q6P179 | 3/20 | 0.34 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.33 |
| ▸ | CTSB | P07858 | 3/20 | 0.33 |
| ▸ | CTSK | P43235 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7319509 | 1.00 | CTSD (0.37) | CTSDRENIL1RNERAP2ERAP1 | |
| SCHEMBL10447998 | 0.85 | REN (0.42) | CTSDREN | |
| SCHEMBL10447999 | 0.85 | REN (0.42) | CTSDREN | |
| SCHEMBL7319519 | 0.84 | REN (0.48) | RENCTSBCTSK | |
| SCHEMBL10431112 | 0.76 | REN (0.48) | CTSDREN | |
| Hydrochloric Acid SCHEMBL10448582 | 0.75 | ALDH1A1 (0.36) | IL1RNERAP2ERAP1 | |
| Hydrochloric Acid SCHEMBL10448581 | 0.75 | ALDH1A1 (0.36) | IL1RNERAP2ERAP1 | |
| SCHEMBL11426067 | 0.75 | PSENEN (0.46) | CTSDRENCTSK | |
| SCHEMBL11426063 | 0.75 | PSENEN (0.46) | CTSDRENCTSK | |
| SCHEMBL10659887 | 0.74 | REN (0.60) | CTSDREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0437508-A1 | NON-PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1991-07-24 | — | — | EP | disclosed |
| WO-1990003971-A1 | NON-PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1990-04-19 | — | — | WO | disclosed |