Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.53 |
| ▸ | OGG1 | O15527 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7318669 | 0.87 | SLC6A4 (0.49) | SLC6A4 | |
| SCHEMBL7317062 | 0.86 | SLC6A4 (0.54) | SLC6A4IDO1TDO2ALDH1A1CNR1 | |
| SCHEMBL7310188 | 0.85 | LMNA (0.47) | SLC6A4 | |
| SCHEMBL7409524 | 0.79 | SLC6A4 (0.49) | SLC6A4ALDH1A1MAPTSLC6A2SLC6A3 | |
| SCHEMBL7310728 | 0.79 | SLC6A9 (0.49) | SLC6A4FNTAFNTBALDH1A1 | |
| SCHEMBL18228682 | 0.78 | SLC6A4 (0.60) | SLC6A4OGG1FNTAFNTBALDH1A1 | |
| SCHEMBL21391835 | 0.78 | SLC6A4 (0.60) | SLC6A4OGG1FNTAFNTBALDH1A1 | |
| SCHEMBL18228719 | 0.78 | SLC6A4 (0.60) | SLC6A4OGG1FNTAFNTBALDH1A1 | |
| Oxalic Acid SCHEMBL7319549 | 0.76 | SLC6A4 (0.62) | SLC6A4OGG1IDO1TDO2SLC6A2 | |
| SCHEMBL7306077 | 0.76 | SLC6A4 (0.59) | SLC6A4ALDH1A1SLC6A2SLC6A3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4626549-A | Treatment of obesity with aryloxyphenylpropylamines | ELI LILLY AND COMPANY (US) | 1986-12-02 | — | — | US | disclosed |
| US-4314081-A | ANTIDEPRESSANTS | ELI LILLY AND COMPANY (US) | 1982-02-02 | — | — | US | disclosed |
| US-4194009-A | ANTIDEPRESSANT | ELI LILLY AND COMPANY (US) | 1980-03-18 | — | — | US | disclosed |
| US-4018895-A | Aryloxyphenylpropylamines in treating depression | ELI LILLY AND COMPANY (US) | 1977-04-19 | — | — | US | disclosed |