Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 14/20 | 0.45 |
| ▸ | PPARA | Q07869 | 14/20 | 0.45 |
| ▸ | SCN4A | P35499 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7319558 | 0.87 | SLC6A4 (0.53) | SLC6A4 | |
| SCHEMBL7310728 | 0.86 | SLC6A9 (0.49) | SLC6A4SLC6A9PPARGPPARAHTR1A | |
| SCHEMBL7409524 | 0.86 | SLC6A4 (0.49) | SLC6A4SLC6A9PPARGPPARAHTR1A | |
| SCHEMBL7306077 | 0.83 | SLC6A4 (0.59) | SLC6A4SLC6A9 | |
| SCHEMBL5027210 | 0.82 | SLC6A9 (0.47) | SLC6A4SLC6A9PPARGPPARAHTR1A | |
| SCHEMBL7317062 | 0.80 | SLC6A4 (0.54) | SLC6A4PPARGPPARA | |
| SCHEMBL4936018 | 0.79 | CYP1A2 (0.43) | SLC6A4SLC6A9PPARGPPARASCN4A | |
| SCHEMBL7310188 | 0.79 | LMNA (0.47) | SLC6A4 | |
| SCHEMBL7317723 | 0.76 | PPARG (0.45) | SLC6A4PPARGPPARA | |
| SCHEMBL7311168 | 0.76 | KMT2A (0.50) | SLC6A4SLC6A9HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4626549-A | Treatment of obesity with aryloxyphenylpropylamines | ELI LILLY AND COMPANY (US) | 1986-12-02 | — | — | US | disclosed |
| US-4314081-A | ANTIDEPRESSANTS | ELI LILLY AND COMPANY (US) | 1982-02-02 | — | — | US | disclosed |
| US-4194009-A | ANTIDEPRESSANT | ELI LILLY AND COMPANY (US) | 1980-03-18 | — | — | US | disclosed |
| US-4018895-A | Aryloxyphenylpropylamines in treating depression | ELI LILLY AND COMPANY (US) | 1977-04-19 | — | — | US | disclosed |