Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 8/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5027210 | 0.95 | SLC6A9 (0.47) | SLC6A9PPARGPPARAHTR1ANPSR1 | |
| SCHEMBL4936018 | 0.92 | CYP1A2 (0.43) | SLC6A9PPARGPPARAHTR1ANPSR1 | |
| SCHEMBL7318669 | 0.86 | SLC6A4 (0.49) | SLC6A9PPARGPPARAHTR1ASLC6A4 | |
| SCHEMBL7409524 | 0.86 | SLC6A4 (0.49) | SLC6A9PPARGPPARAHTR1ANPSR1 | |
| SCHEMBL7306077 | 0.83 | SLC6A4 (0.59) | SLC6A9ALDH1A1HPGDSLC6A4LMNA | |
| SCHEMBL16347642 | 0.82 | SLC6A9 (0.47) | SLC6A9PPARGPPARAHTR1ANPSR1 | |
| SCHEMBL7310188 | 0.82 | LMNA (0.47) | SLC6A4LMNA | |
| SCHEMBL143604 | 0.82 | SLC6A9 (0.45) | SLC6A9PPARGPPARAHTR1ASLC6A4 | |
| SCHEMBL7317062 | 0.80 | SLC6A4 (0.54) | PPARGPPARAALDH1A1HPGDSLC6A4 | |
| SCHEMBL5533205 | 0.80 | SLC6A9 (0.46) | SLC6A9HTR1ANPSR1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4626549-A | Treatment of obesity with aryloxyphenylpropylamines | ELI LILLY AND COMPANY (US) | 1986-12-02 | — | — | US | disclosed |
| US-4314081-A | ANTIDEPRESSANTS | ELI LILLY AND COMPANY (US) | 1982-02-02 | — | — | US | disclosed |
| US-4194009-A | ANTIDEPRESSANT | ELI LILLY AND COMPANY (US) | 1980-03-18 | — | — | US | disclosed |
| US-4018895-A | Aryloxyphenylpropylamines in treating depression | ELI LILLY AND COMPANY (US) | 1977-04-19 | — | — | US | disclosed |