Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 2/20 | 0.52 |
| ▸ | ELANE | P08246 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.52 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.52 |
| ▸ | CDC25B | P30305 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 3/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.49 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL983965 | 0.98 | LMNA (0.54) | ELANELMNACYP1A2CYP3A4MAOA | |
| SCHEMBL29370485 | 0.98 | LMNA (0.54) | ELANELMNACYP1A2CYP3A4MAOA | |
| SCHEMBL285618 | 0.98 | LMNA (0.54) | ELANELMNACYP1A2CYP3A4MAOA | |
| Methane SCHEMBL2132580 | 0.97 | ELANE (0.53) | ELANELMNACYP1A2CYP3A4MAOA | |
| Hydrochloric Acid SCHEMBL642777 | 0.92 | LMNA (0.61) | ELANELMNACYP1A2CYP3A4MAOA | |
| SCHEMBL29465556 | 0.91 | LMNA (0.62) | ELANELMNACYP1A2CYP3A4MAOA | |
| SCHEMBL133366 | 0.91 | LMNA (0.62) | ELANELMNACYP1A2CYP3A4MAOA | |
| Ethylamine SCHEMBL27494386 | 0.89 | LMNA (0.57) | ELANELMNACYP1A2CYP3A4MAOA | |
| Methane SCHEMBL15286491 | 0.89 | LMNA (0.61) | ELANELMNACYP1A2CYP3A4MAOA | |
| 3-Aminobenzoic Acid SCHEMBL8220213 | 0.85 | LMNA (0.56) | ELANELMNACYP1A2CYP3A4MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114931594-B | Ointment for stopping bleeding and relieving pain of anus and preparation method thereof | 北京中泰邦医药科技有限公司 | 2023-10-13 | — | — | CN | claimed |
| CN-115403479-A | Crystalline form of trimecaine hydrochloride hemi-hydrate and preparation method thereof | 上海应用技术大学 | 2022-11-29 | — | — | CN | claimed |
| CN-114931594-A | Ointment for stopping bleeding and relieving pain of anus and preparation method thereof | 北京中泰邦医药科技有限公司 | 2022-08-23 | — | — | CN | claimed |
| CN-114436879-A | Preparation method of trimethylcaine hydrochloride | 海南三帝制药有限公司 | 2022-05-06 | — | — | CN | claimed |
| CN-111004143-A | One-pot production process of tricaine hydrochloride | 山东诚汇双达药业有限公司 | 2020-04-14 | — | — | CN | claimed |
| CN-114931594-B | Ointment for stopping bleeding and relieving pain of anus and preparation method thereof | 北京中泰邦医药科技有限公司 | 2023-10-13 | — | — | CN | disclosed |
| CN-114931594-B | Ointment for stopping bleeding and relieving pain of anus and preparation method thereof | 北京中泰邦医药科技有限公司 | 2023-10-13 | — | — | CN | disclosed |
| CN-115403479-A | Crystalline form of trimecaine hydrochloride hemi-hydrate and preparation method thereof | 上海应用技术大学 | 2022-11-29 | — | — | CN | disclosed |
| CN-217772643-U | Cold plaster for botulinum toxin injection anesthesia | 华东医院 | 2022-11-11 | — | — | CN | disclosed |
| CN-114931594-A | Ointment for stopping bleeding and relieving pain of anus and preparation method thereof | 北京中泰邦医药科技有限公司 | 2022-08-23 | — | — | CN | disclosed |
| CN-114931594-A | Ointment for stopping bleeding and relieving pain of anus and preparation method thereof | 北京中泰邦医药科技有限公司 | 2022-08-23 | — | — | CN | disclosed |
| CN-114436879-A | Preparation method of trimethylcaine hydrochloride | 海南三帝制药有限公司 | 2022-05-06 | — | — | CN | disclosed |
| CN-111004143-A | One-pot production process of tricaine hydrochloride | 山东诚汇双达药业有限公司 | 2020-04-14 | — | — | CN | disclosed |
| US-6387392-B1 | COMPRISING A PRESSURE-SENSITIVE ADHESIVE LAYER CONTAINING A DRUG ON A CLOTH WHICH PREVENTS THE DILUTION OF DRUG BY SALIVA | NITTO DENKO CORPORATION (JP) | 2002-05-14 | — | — | US | disclosed |
| US-20020051753-A1 | INTRAORAL ADHESIVE PREPARATION | NITTO DENKO CORPORATION (JP) | 2002-05-02 | — | — | US | disclosed |
| EP-1181931-A2 | Intraoral adhesive preparation | NITTO DENKO CORPORATION (JP) | 2002-02-27 | — | — | EP | disclosed |
| US-5424218-A | Measuring binding affinity of compound to omega conotoxin binding site and ability to inhibit voltage-gated calcium currents or neurotransmitter release | NEUREX CORPORATION (US) | 1995-06-13 | — | — | US | disclosed |
| US-5364842-A | Method of producing analgesia | NEUREX CORPORATION (US) | 1994-11-15 | — | — | US | disclosed |
| US-5264371-A | Binding of proteins and conotoxin for antiischemic agents | NEUREX CORPORATION (US) | 1993-11-23 | — | — | US | disclosed |
| US-5051403-A | Treatment of strokes with peptides | NEUREX CORPORATION (US) | 1991-09-24 | — | — | US | disclosed |