Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 known ✓ | P00734 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.46 |
| ▸ | ACR | P10323 | 3/20 | 0.43 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.43 |
| ▸ | KLK1 | P06870 | 2/20 | 0.43 |
| ▸ | F10 | P00742 | 2/20 | 0.43 |
| ▸ | C1R | P00736 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7319782 | 0.93 | KMT2A (0.46) | KMT2AMEN1SMN1; SMN2FTOACR | |
| SCHEMBL7319785 | 0.91 | KMT2A (0.46) | KMT2AMEN1SMN1; SMN2FTOACR | |
| SCHEMBL9690496 | 0.88 | KMT2A (0.42) | KMT2AMEN1SMN1; SMN2FTOACR | |
| SCHEMBL9835889 | 0.86 | KMT2A (0.44) | KMT2AMEN1SMN1; SMN2FTOACR | |
| SCHEMBL9835061 | 0.86 | KMT2A (0.48) | KMT2AMEN1SMN1; SMN2ACRPRSS1 | |
| Acetic Acid SCHEMBL7314947 | 0.84 | KMT2A (0.45) | KMT2AMEN1SMN1; SMN2FTOACR | |
| SCHEMBL9584464 | 0.83 | ALDH1A1 (0.45) | KMT2AMEN1SMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL9690520 | 0.82 | KMT2A (0.45) | KMT2AMEN1SMN1; SMN2ACRPRSS1 | |
| SCHEMBL9690405 | 0.82 | PPARG (0.50) | KMT2AMEN1SMN1; SMN2FTOTMPRSS15 | |
| Acetic Acid SCHEMBL7307745 | 0.82 | KMT2A (0.47) | KMT2AMEN1SMN1; SMN2ACRPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5376655-A | Elastase inhibitor | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-12-27 | — | — | US | disclosed |
| US-5247084-A | Inhibitors of elastase | ONO PHARMACEUTICAL CO., LTD. (JP) | 1993-09-21 | — | — | US | disclosed |
| US-5077428-A | Antiinflammatory agents | ONO PHARMACEUTICAL CO., LTD. (JP) | 1991-12-31 | — | — | US | disclosed |
| EP-0222608-B1 | DERIVATIVES OF P-GUANIDINOBENZOIC ACID AND PHARMACEUTICAL AGENTS CONTAINING THEM AS ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 1991-09-11 | — | — | EP | disclosed |
| US-4975464-A | ADMINISTERING DERIVATIVES OF P-GUANIDINOBENZOIC ACID | IMAKI KATSUHIRO (JP) | 1990-12-04 | — | — | US | disclosed |
| US-4843094-A | ELASTASE INHIBITOR | ONO PHARMACEUTICAL CO., LTD. (JP) | 1989-06-27 | — | — | US | disclosed |
| EP-0222608-A2 | Derivatives of p-guanidinobenzoic acid and pharmaceutical agents containing them as active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 1987-05-20 | — | — | EP | disclosed |