Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 6/20 | 0.53 |
| ▸ | KMO | O15229 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CPA1 | P15085 | 2/20 | 0.46 |
| ▸ | CPB1 | P15086 | 1/20 | 0.46 |
| ▸ | CPA3 | P15088 | 1/20 | 0.46 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7320178 | 0.89 | KMO (0.54) | AKR1C3KMOHDAC2HDAC8HDAC6 | |
| SCHEMBL7314484 | 0.83 | KMO (0.57) | KMOCPA1CPB1CPA3CPB2 | |
| SCHEMBL7316863 | 0.82 | ALDH1A1 (0.58) | KMOLMNAALDH1A1SMN1; SMN2CPA1 | |
| SCHEMBL7321264 | 0.81 | ALDH1A1 (0.54) | HDAC2HDAC8HDAC6HTTLMNA | |
| SCHEMBL7312441 | 0.77 | KMO (0.63) | KMOMAPTALDH1A1CPA1CPB1 | |
| SCHEMBL7319825 | 0.77 | MAPT (0.58) | KMOHTTLMNAMAPTALDH1A1 | |
| SCHEMBL13614936 | 0.77 | CYP2C19 (0.70) | AKR1C3HTTLMNA | |
| SCHEMBL3104186 | 0.76 | TSHR (0.75) | KMOCPA1CPB1CPA3CPB2 | |
| SCHEMBL7315538 | 0.76 | TSHR (0.75) | KMOCPA1CPB1CPA3CPB2 | |
| SCHEMBL7312457 | 0.75 | KMO (0.71) | KMOCPA1CPB1CPA3CPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5459131-A | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1995-10-17 | — | — | US | disclosed |