Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.55 |
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
| ▸ | MC3R | P41968 | 1/20 | 0.46 |
| ▸ | GRIA1 | P42261 | 7/20 | 0.45 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.45 |
| ▸ | CHRNG | P07510 | 2/20 | 0.45 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.45 |
| ▸ | CHRND | Q07001 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7319791 | 0.84 | REN (0.50) | RENMC4RMC3RHDAC3HDAC4 | |
| SCHEMBL7327795 | 0.84 | REN (0.53) | RENMC4RMC3RGRIA1CHRNA1 | |
| SCHEMBL7325202 | 0.78 | REN (0.49) | RENMC4RMC3R | |
| SCHEMBL18235814 | 0.77 | MC4R (0.54) | RENMC4RMC3R | |
| SCHEMBL22566158 | 0.76 | MC3R (0.58) | RENMC4RMC3RHDAC1HDAC6 | |
| SCHEMBL398742 | 0.74 | CHRNA1 (0.64) | GRIA1CHRNA1CHRNGCHRNB1CHRND | |
| SCHEMBL21498146 | 0.74 | MAPT (0.45) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL18232425 | 0.72 | MC3R (0.52) | RENMC4RMC3RHDAC3HDAC4 | |
| SCHEMBL21498143 | 0.72 | REN (0.55) | RENMC4RMC3R | |
| SCHEMBL7328587 | 0.72 | CYP3A4 (0.59) | GRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5218000-A | Nervous system disorders, antiischemic agents | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1993-06-08 | — | — | US | disclosed |
| EP-0361687-A1 | Therapeutic polyamine-amides | BTG INTERNATIONAL LIMITED (GB) | 1990-04-04 | — | — | EP | disclosed |
| WO-1990002114-A1 | THERAPEUTIC POLYAMINE-AMIDES | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1990-03-08 | — | — | WO | disclosed |