Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.53 |
| ▸ | CHRNA1 | P02708 | 3/20 | 0.48 |
| ▸ | CHRNG | P07510 | 3/20 | 0.48 |
| ▸ | CHRNB1 | P11230 | 3/20 | 0.48 |
| ▸ | CHRND | Q07001 | 3/20 | 0.48 |
| ▸ | MC4R | P32245 | 3/20 | 0.48 |
| ▸ | MC3R | P41968 | 3/20 | 0.48 |
| ▸ | MC5R | P33032 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7320232 | 0.84 | REN (0.55) | RENCHRNA1CHRNGCHRNB1CHRND | |
| SCHEMBL7325202 | 0.77 | REN (0.49) | RENMC4RMC3RMC5R | |
| SCHEMBL7323616 | 0.77 | CHRNA1 (0.67) | CHRNA1CHRNGCHRNB1CHRNDGRIA1 | |
| SCHEMBL7319791 | 0.75 | REN (0.50) | RENMC4RMC3R | |
| SCHEMBL22566158 | 0.75 | MC3R (0.58) | RENMC4RMC3RMC5R | |
| SCHEMBL21498143 | 0.74 | REN (0.55) | RENMC4RMC3RMC5R | |
| SCHEMBL5093230 | 0.73 | DRD2 (0.65) | DRD2DRD1TAAR1ENPP2 | |
| SCHEMBL19445930 | 0.72 | TRPV1 (0.47) | CHRNA1CHRNGCHRNB1CHRNDDRD1 | |
| SCHEMBL7328587 | 0.71 | CYP3A4 (0.59) | — | |
| SCHEMBL21498146 | 0.70 | MAPT (0.45) | DRD2DRD1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5218000-A | Nervous system disorders, antiischemic agents | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1993-06-08 | — | — | US | disclosed |
| EP-0361687-A1 | Therapeutic polyamine-amides | BTG INTERNATIONAL LIMITED (GB) | 1990-04-04 | — | — | EP | disclosed |
| WO-1990002114-A1 | THERAPEUTIC POLYAMINE-AMIDES | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1990-03-08 | — | — | WO | disclosed |