Sugi Predict

Sugi Predict / Compounds / SCHEMBL7320511

SCHEMBL7320511

SCHEMBL7320511

Cc1ccc(C2(O)c3ccccc3-c3ccccc32)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDK2 Q15119 6/20 0.47
▸ ESR1 P03372 1/20 0.44
▸ ESR2 Q92731 1/20 0.44
▸ KIF11 P52732 1/20 0.43
▸ MDM2 Q00987 1/20 0.41
▸ THRB P10828 1/20 0.41
▸ TDP1 Q9NUW8 1/20 0.41
▸ GFER P55789 1/20 0.41
▸ OPRK1 P41145 2/20 0.39
▸ KDM4E B2RXH2 1/20 0.39
▸ MEN1 O00255 1/20 0.39
▸ LMNA P02545 1/20 0.39
▸ MAPT P10636 1/20 0.39
▸ KMT2A Q03164 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ OPRM1 P35372 2/20 0.39
▸ OPRL1 P41146 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.38
▸ L3MBTL1 Q9Y468 1/20 0.38
▸ PGR P06401 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1758080 0.89 OPRM1 (0.42) PDK2ESR1ESR2KIF11MDM2
SCHEMBL19039047 0.89 PDK2 (0.50) PDK2ESR1ESR2THRBTDP1
SCHEMBL30281291 0.89 PDK2 (0.50) PDK2ESR1ESR2THRBTDP1
SCHEMBL11451560 0.89 ELANE (0.44) PDK2KIF11MDM2TDP1GFER
SCHEMBL22071209 0.85 PDK2 (0.51) PDK2ESR1ESR2KIF11MDM2
SCHEMBL7314066 0.83 PDK2 (0.57) PDK2ESR1ESR2THRBTDP1
SCHEMBL7315823 0.83 PDK2 (0.61) PDK2ESR1ESR2THRBTDP1
SCHEMBL12176923 0.83 PDK2 (0.47) PDK2ESR1ESR2KIF11MDM2
SCHEMBL17471968 0.83 PDK2 (0.59) PDK2ESR1ESR2MEN1KMT2A
SCHEMBL14970800 0.83 PDK2 (0.45) PDK2ESR1ESR2THRBTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9029504-B2 Fluorene compound AJINOMOTO CO., INC. (JP) 2015-05-12 — — US disclosed
US-20140046022-A1 FLUORENE COMPOUND AJINOMOTO CO., INC. (JP) 2014-02-13 — — US disclosed
US-8569453-B2 Fluorene compound AJINOMOTO CO., INC. (JP) 2013-10-29 — — US disclosed
US-20100240867-A1 FLUORENE COMPOUND AJINOMOTO CO. INC. (JP) 2010-09-23 — — US disclosed
CN-101747208-A Non-conjugated derivative material with fluorine-triphenylamine structure and synthesis method thereof UNIV ZHEJIANG TECHNOLOGY 2010-06-23 — — CN disclosed
US-6162824-A NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS ALLELIX NEUROSCIENCE INC. 2000-12-19 — — US disclosed
WO-1999041227-A1 TRICYCLIC COMPOUNDS AS GLYCINE TRANSPORT INHIBITORS ALLELIX NEUROSCIENCE, INC. (US) 1999-08-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140046022-A1 FLUORENE COMPOUND NPPA, FURIN, SFPQ PDK2 3174/4885ESR1 1695/4885ESR2 2414/4885
US-20100240867-A1 FLUORENE COMPOUND NPPA, FURIN, SFPQ PDK2 3174/4885ESR1 1695/4885ESR2 2414/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.