Silvestrol

Silvestrol

SCHEMBL732092

COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(OC)cc(O[C@@H]4O[C@@H]([C@H](O)CO)CO[C@H]4OC)cc3O[C@@]2(c2ccc(OC)cc2)[C@@H]1c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
EIF4A1 P60842 19/20 1.00
CYP3A4 P08684 1/20 0.68
HIF1A Q16665 1/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Silvestrol SCHEMBL29391620 1.00 EIF4A1 (1.00) EIF4A1CYP3A4HIF1A
Silvestrol SCHEMBL19678561 1.00 EIF4A1 (1.00) EIF4A1CYP3A4HIF1A
2'-Episilvestrol SCHEMBL29384144 1.00 EIF4A1 (1.00) EIF4A1CYP3A4HIF1A
Silvestrol SCHEMBL19683897 1.00 EIF4A1 (1.00) EIF4A1CYP3A4HIF1A
Silvestrol SCHEMBL24180257 1.00 EIF4A1 (1.00) EIF4A1CYP3A4HIF1A
Silvestrol SCHEMBL19666161 1.00 EIF4A1 (1.00) EIF4A1CYP3A4HIF1A
Silvestrol SCHEMBL24426807 1.00 EIF4A1 (1.00) EIF4A1CYP3A4HIF1A
Silvestrol SCHEMBL29959484 1.00 EIF4A1 (1.00) EIF4A1CYP3A4HIF1A
Silvestrol SCHEMBL5807124 1.00 EIF4A1 (1.00) EIF4A1CYP3A4HIF1A
Silvestrol SCHEMBL19508495 1.00 EIF4A1 (1.00) EIF4A1CYP3A4HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 453 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4714452-A1 METHODS FOR TREATING SARS COV-2 INFECTIONS Gilead Sciences, Inc. (US) 2026-03-25 EP claimed
US-20250255894-A1 INHIBITORS OF EIF4A Aceae Nutra Limited (GB) 2025-08-14 US claimed
WO-2025137577-A1 SHORT VIRAL RNAS (SVRNAS) WITH THERAGNOSTIC POTENTIAL IN INFECTION WITH SARS-COV-2 AND RELATED VIRUSES THE JOHNS HOPKINS UNIVERSITY (US) 2025-06-26 WO claimed
EP-4554571-A2 EIF4A INHIBITORS AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-05-21 EP claimed
WO-2025093619-A1 BOOSTING CAP-INDEPENDENT TRANSLATION CIRCIO AB (SE) 2025-05-08 WO claimed
WO-2025071306-A1 PHARMACEUTICAL COMPOSITION FOR TREATING LYMPHOMA COMPRISING BCL-2 INHIBITOR, SELECTIVE NUCLEAR EXPORT PROTEIN INHIBITOR, AND ELF4A INHIBITOR 연세대학교 산학협력단 2025-04-03 WO claimed
EP-4489763-A1 INHIBITORS OF EIF4A Aceae Nutra Limited (GB) 2025-01-15 EP claimed
US-20240393340-A1 PROGNOSIS AND PREDICTIVE BIOMARKERS AND BIOLOGICAL APPLICATIONS THEREOF Institut National de la Santé et de la Recherche Médicale (FR) 2024-11-28 US claimed
WO-2024107624-A1 METHODS OF OVERCOMING RESISTANCE TO CHECKPOINT INHIBITOR THERAPIES SHATTUCK LABS, INC. (US) 2024-05-23 WO claimed
WO-2024016000-A2 EIF4A INHIBITORS AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-01-18 WO claimed
US-20150224132-A1 COMPOSITIONS AND METHODS FOR TREATING FIBROTIC DISEASE OXFORD FINANCE LLC, AS COLLATERAL AGENT 2015-08-13 US claimed
WO-2015120350-A2 COMPOSITIONS AND METHODS FOR TREATING FIBROTIC DISEASE EFFECTOR THERAPEUTICS, INC. (US) 2015-08-13 WO claimed
US-20150219624-A1 METHODS FOR IDENTIFYING ANTI-CANCER COMPOUNDS MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2015-08-06 US claimed
WO-2015085221-A2 METHODS FOR IDENTIFYING ANTI-CANCER COMPOUNDS MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2015-06-11 WO claimed
US-20150087598-A1 TREATING MUC1-EXPRESSING CANCERS WITH HELICASE INHIBITORS DANA-FARBER CANCER INSTITUTE, INC. (US) 2015-03-26 US claimed
WO-2014184211-A1 PROGNOSIS AND PREDICTIVE BIOMARKERS AND BIOLOGICAL APPLICATIONS THEREOF INSTITUT GUSTAVE ROUSSY (FR) 2014-11-20 WO claimed
US-20140255432-A1 SILVESTROL, SILVESTROL ANALOGS AND USES THEREOF OHIO STATE INNOVATION FOUNDATION (US) 2014-09-11 US claimed
WO-2013170257-A1 TREATING MUC1-EXPRESSING CANCERS WITH HELICASE INHIBITORS DANA-FARBER CANCER INSTITUTE, INC. (US) 2013-11-14 WO claimed
WO-2013016658-A1 SILVESTROL, SILVESTROL ANALOGS AND USES THEREOF THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) 2013-01-31 WO claimed
US-20090186839-A1 Model for studying the role of genes in chemoresistance COLD SPRING HARBOR LABORATORY (US) 2009-07-23 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150087598-A1 TREATING MUC1-EXPRESSING CANCERS WITH HELICASE INHIBITORS MUC1, DDX21, DDX39B EIF4A1 30/4885CYP3A4 4608/4885HIF1A 1690/4885
US-20140255432-A1 SILVESTROL, SILVESTROL ANALOGS AND USES THEREOF CD4, HAVCR2, IFNG EIF4A1 2206/4885CYP3A4 2559/4885HIF1A 1552/4885
US-20250255894-A1 INHIBITORS OF EIF4A EIF4A1, EIF4EBP1, EIF4E EIF4A1 1/4885CYP3A4 4495/4885HIF1A 1414/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.