Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.71 |
| ▸ | AOC2 | O75106 | 2/20 | 0.71 |
| ▸ | MAOA | P21397 | 2/20 | 0.71 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.71 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.40 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.37 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.37 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.37 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7322207 | 1.00 | MAOB (0.71) | MAOBAOC2MAOAAOC3FFAR1 | |
| SCHEMBL8585905 | 0.83 | AOC2 (0.69) | MAOBAOC2MAOAAOC3FFAR1 | |
| SCHEMBL8585089 | 0.83 | MAOB (0.69) | MAOBAOC2MAOAAOC3FFAR1 | |
| Mofegiline SCHEMBL1295041 | 0.83 | MAOB (1.00) | MAOBAOC2MAOAAOC3FFAR1 | |
| SCHEMBL14005455 | 0.83 | AOC3 (0.69) | MAOBAOC2MAOAAOC3FFAR1 | |
| Mofegiline SCHEMBL147813 | 0.83 | MAOB (1.00) | MAOBAOC2MAOAAOC3FFAR1 | |
| Mofegiline SCHEMBL1295043 | 0.83 | MAOB (1.00) | MAOBAOC2MAOAAOC3FFAR1 | |
| Mofegiline SCHEMBL14005358 | 0.83 | MAOB (1.00) | MAOBAOC2MAOAAOC3FFAR1 | |
| SCHEMBL8585907 | 0.83 | AOC2 (0.69) | MAOBAOC2MAOAAOC3FFAR1 | |
| SCHEMBL8585084 | 0.83 | MAOB (0.69) | MAOBAOC2MAOAAOC3FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784604-B1 | PROCESS FOR THE PREPARATION OF (E)-2-FLUOROMETHYLENE-4-(4-FLUOROPHENYL) BUTAN-1-OL | HOECHST MARION ROUSSEL INC (US) | 1999-11-17 | — | — | EP | claimed |
| EP-0875499-A2 | Process for the crystallisation of alkali metal salts of diformylamide | HOECHST MARION ROUSSEL, INC. (US) | 1998-11-04 | — | — | EP | claimed |
| US-5679854-A | Process for the preparation of (epsilon)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane and novel intermediate thereof | HOECHST MARION ROUSSEL, INC. (US) | 1997-10-21 | — | — | US | claimed |
| EP-0295604-A1 | (E)-2-(p-Fluorophenethyl)-3-fluoroallylamine | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-12-21 | — | — | EP | claimed |
| JP-1016752-A | — | — | None | — | — | JP | disclosed |
| EP-0784604-B1 | PROCESS FOR THE PREPARATION OF (E)-2-FLUOROMETHYLENE-4-(4-FLUOROPHENYL) BUTAN-1-OL | HOECHST MARION ROUSSEL INC (US) | 1999-11-17 | — | — | EP | disclosed |
| EP-0784604-B1 | PROCESS FOR THE PREPARATION OF (E)-2-FLUOROMETHYLENE-4-(4-FLUOROPHENYL) BUTAN-1-OL | HOECHST MARION ROUSSEL INC (US) | 1999-11-17 | — | — | EP | disclosed |
| EP-0875499-A2 | Process for the crystallisation of alkali metal salts of diformylamide | HOECHST MARION ROUSSEL, INC. (US) | 1998-11-04 | — | — | EP | disclosed |
| US-5679854-A | Process for the preparation of (epsilon)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane and novel intermediate thereof | HOECHST MARION ROUSSEL, INC. (US) | 1997-10-21 | — | — | US | disclosed |
| US-5679854-A | Process for the preparation of (epsilon)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane and novel intermediate thereof | HOECHST MARION ROUSSEL, INC. (US) | 1997-10-21 | — | — | US | disclosed |
| CN-1159179-A | Processes for preparation of (E)-2-fluoromethylene-4-(4-fluorophenyl) butylamine and alkali metal salts of diformylamide | HOECHST MARION ROUSSEL INC (US) | 1997-09-10 | — | — | CN | disclosed |
| EP-0784604-A1 | PROCESSES FOR THE PREPARATION OF (E)-2-FLUOROMETHYLENE-4-(4-FLUOROPHENYL) BUTYLAMINE AND ALKALI METAL SALTS OF DIFORMYLAMIDE | HOECHST MARION ROUSSEL, INC. (US) | 1997-07-23 | — | — | EP | disclosed |
| EP-0720475-A1 | TRANSDERMAL DEVICE CONTAINING (E)-2-(P-FLUOROPHENETHYL)-3-FLUOROALLYLAMINE FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-10 | — | — | EP | disclosed |
| WO-1996010003-A1 | PROCESSES FOR THE PREPARATION OF (E)-2-FLUOROMETHYLENE-4-(4-FLUOROPHENYL) BUTYLAMINE AND ALKALI METAL SALTS OF DIFORMYLAMIDE | HOECHST MARION ROUSSEL, INC. (US) | 1996-04-04 | — | — | WO | disclosed |
| US-5488188-A | Process for the preparation of (E)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane, novel processes for preparing an intermediate thereof, and novel intermediates thereof | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-01-30 | — | — | US | disclosed |
| US-5488188-A | Process for the preparation of (E)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane, novel processes for preparing an intermediate thereof, and novel intermediates thereof | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-01-30 | — | — | US | disclosed |
| WO-1995008325-A1 | TRANSDERMAL DEVICE CONTAINING (E)-2-(P-FLUOROPHENETHYL)-3-FLUOROALLYLAMINE FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERRELL PHARMACEUTICALS INC. (US) | 1995-03-30 | — | — | WO | disclosed |
| EP-0642338-A1 | USE OF (E)-2-(p-FLUOROPHENETHYL)-3-FLUOROALLYLAMINE IN THE TREATEMENT OF ALZHEIMER'S DISEASE. | MERRELL DOW PHARMA (US) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993024120-A1 | USE OF (E)-2-(p-FLUOROPHENETHYL)-3-FLUOROALLYLAMINE IN THE TREATEMENT OF ALZHEIMER'S DISEASE | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-12-09 | — | — | WO | disclosed |
| EP-0295604-A1 | (E)-2-(p-Fluorophenethyl)-3-fluoroallylamine | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-12-21 | — | — | EP | disclosed |