Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 9/20 | 0.48 |
| ▸ | MMP9 | P14780 | 5/20 | 0.44 |
| ▸ | MMP1 | P03956 | 3/20 | 0.44 |
| ▸ | MMP13 | P45452 | 3/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | MMP7 | P09237 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7318036 | 0.83 | NAMPT (0.46) | NAMPTMMP9MMP1MMP13MMP3 | |
| SCHEMBL7323621 | 0.79 | NAMPT (0.44) | NAMPTMMP9MMP1MMP13MMP3 | |
| SCHEMBL7314523 | 0.77 | NAMPT (0.55) | NAMPTMMP9MMP1MMP13ALDH1A1 | |
| SCHEMBL7322218 | 0.76 | NAMPT (0.55) | NAMPTMMP9MMP1MMP13ALDH1A1 | |
| SCHEMBL7314654 | 0.73 | MMP9 (0.46) | NAMPTMMP9MMP1MMP13ALDH1A1 | |
| SCHEMBL7324058 | 0.73 | NAMPT (0.49) | NAMPTMMP9MMP1MMP13ALDH1A1 | |
| SCHEMBL7318051 | 0.72 | KEAP1 (0.49) | NAMPTMMP9MMP1MMP13ALDH1A1 | |
| SCHEMBL7319935 | 0.72 | NAMPT (0.48) | NAMPTMMP9MMP1MMP13ALDH1A1 | |
| SCHEMBL7311380 | 0.72 | NAMPT (0.48) | NAMPTMMP9MMP1MMP13ALDH1A1 | |
| Iodomethane SCHEMBL11489390 | 0.71 | GAA (0.60) | ALDH1A1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929097-A | INHIBIT TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME | AMERICAN CYANAMID COMPANY (US) | 1999-07-27 | — | — | US | disclosed |